Changes in classification of genetic variants in BRCA1 and BRCA2
ConclusionAll variants with a change in classification in our cohort were down-staged towards no clinical significance by a panel of experts of the German Consortium for Hereditary Breast and Ovarian Cancer (GC-HBOC). Prevention in families with Class 3 variants should be based on pedigree based risks and should not be guided by the presence of a VUS.
Source: Archives of Gynecology and Obstetrics - Category: OBGYN Source Type: research
More News: Breast Cancer | Cancer | Cancer & Oncology | Databases & Libraries | Genetics | Germany Health | OBGYN | Ovarian Cancer | Ovaries