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Changes in classification of genetic variants in BRCA1 and BRCA2

ConclusionAll variants with a change in classification in our cohort were down-staged towards no clinical significance by a panel of experts of the German Consortium for Hereditary Breast and Ovarian Cancer (GC-HBOC). Prevention in families with Class 3 variants should be based on pedigree based risks and should not be guided by the presence of a VUS.
Source: Archives of Gynecology and Obstetrics - Category: OBGYN Source Type: research

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