Increased interleukin ‐36γ expression in skin and sera of patients with atopic dermatitis and mycosis fungoides/Sézary syndrome

In this study, we examined the role of IL‐36γ in atopic dermatitis (AD) and mycosis fungoides (MF)/Sézary syndrome (SS). Serum levels of IL‐36γ in AD patients and MF/SS patients were elevated compared with those of healthy controls. Importantly, serum IL‐36γ levels in AD patients positively correlated with Eczema Area and Severity Index and those of MF/SS patients positively correlated with serum soluble IL‐2 receptor levels. IL‐36γ mRNA levels in AD skin and MF/SS skin were significantly higher than those of normal skin. IL‐36γ mRNA levels in MF/SS skin positively correlated with IL‐17A mRNA levels. Immunohistochemical staining revealed that IL‐36γ was highly expressed in keratinocytes in lesional skin of AD and MF/SS. Taken together, our study demonstrated that IL‐36γ expression was increased in sera and skin of patients with AD and MF/SS as was reported in psoriatic patients.
Source: The Journal of Dermatology - Category: Dermatology Authors: Tags: Concise Communication Source Type: research

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Source: Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Research Paper Source Type: research
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Source: Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Research Paper Source Type: research
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Source: Inflammation - Category: Allergy & Immunology Source Type: research
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Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
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Source: Expert Review of Clinical Immunology - Category: Allergy & Immunology Tags: Expert Rev Clin Immunol Source Type: research
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Source: Clinical Reviews in Allergy and Immunology - Category: Allergy & Immunology Source Type: research
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Source: Journal of General Internal Medicine - Category: Internal Medicine Source Type: research
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Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
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Source: International Journal of Dermatology - Category: Dermatology Authors: Tags: Report Source Type: research
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Source: Journal of Dermatological Science - Category: Dermatology Authors: Tags: P02-17 Source Type: research
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