Reducing avoidable hospital based care: re-thinking out of hospital clinical pathways

This report is intended as a guide for all stakeholders to improve clinical pathways and develop models of care that are less dependent on acute hospitals. Its recommendations are relevant to both acute and long term condition pathways. The report provides a detailed guide to managing acute symptoms and acute conditions out of hospital where safe and appropriate to do so. It also provides detailed guidance on effective common city based pathways for three common long term conditions: heart failure, respiratory conditions and patients living with and beyond cancer.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news

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Abstract Doxorubicin (Doxo) is an effective agent commonly used in cancer therapeutics. Unfortunately, Doxo treatment can stimulate cardiomyopathy and subsequent heart failure, limiting use of this drug. The role of phosphatase and tensin homolog (PTEN) in apoptosis has been documented in Doxo induced cardiomyopathy (DIC) and heart failure models. However, whether direct inhibition of PTEN attenuates apoptosis, cardiac remodeling, and inflammatory M1 macrophages in DIC model remains elusive. Therefore, the current study is designed to understand effects of VO-OHpic (VO), a potent inhibitor of PTEN, in reducing apo...
Source: American Journal of Physiology. Heart and Circulatory Physiology - Category: Physiology Authors: Tags: Am J Physiol Heart Circ Physiol Source Type: research
Purpose of review We aim to summarize the utility of strain in monitoring the effects of cancer therapy-related cardiotoxicity (CTRC) on the development of left ventricular (LV) dysfunction. Recent findings Serial assessment of cardiac function at baseline and during treatment is recommended in patients undergoing cancer treatment. Historically, the use of left ventricular ejection fraction (LVEF) has been used to monitor for cardiac toxicity from cancer therapies but myocardial mechanic parameters, in particular global longitudinal strain (GLS), have emerged as powerful adjunctive tools. On the basis of longitudinal ...
Source: Current Opinion in Cardiology - Category: Cardiology Tags: IMAGING AND HEART FAILURE: MYOCARDIAL STRAIN: Edited by Sherif Nagueh Source Type: research
(CNN) — The US Food and Drug Administration expanded the list of drugs being recalled that contain valsartan. The drug is used as a component in a set of drugs used to treat heart failure and blood pressure. The FDA initially announced a valsartan recall in July after lab tests discovered that some drugs could have been tainted with a substance linked to higher risk of cancer. The drug had previously been recalled in 22 other countries. The expanded recall includes some drugs that contain valsartan and hydrochlorothisazide. Not all of the drugs containing valsartan were impacted. N-nitrosodimethylamine or NDMA, the i...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Consumer Health News Local TV Recall Valsartan Source Type: news
The US Food and Drug Administration expanded the list of drugs being recalled that contain valsartan. The drug is used as a component in a set of drugs used to treat heart failure and blood pressure.
Source: - Health - Category: Consumer Health News Source Type: news
Women who take the chemotherapy drug trastuzumab (Herceptin) for HER2-positive breast cancer can be at higher risk for heart failure and should have their hearts monitored during treatment, new research finds. The complication is not common, and in many cases, the benefits of the chemotherapy still outweigh the risks. But regular checks should be a priority.
Source: WebMD Health - Category: Consumer Health News Source Type: news
Gender inequality in heart attack mortality because 'most physicians are male' Related items fromOnMedica Heart failure treatment based on ‘unrepresentative’ patients Migraine may be linked to heightened cardiovascular disease risk Erectile dysfunction increases cardiovascular risk Higher cancer risk from chronic diseases COPD patients at heightened risk of drug side effects linked to polypharmacy
Source: OnMedica Latest News - Category: UK Health Source Type: news
When it comes to your beverage of choice, alcoholic beverages are unique. For millions, they are a regular part of the dining experience. They’re often an important component of social events, celebrations, and milestones; we toast people, events, and memories with alcohol. They play a key role in many religious traditions. And, of course, the alcoholic beverage industry is a major economic force, responsible for more than $220 billion in sales annually in the US. And all of this is true despite the well-known and well-publicized risks of drinking too much alcohol. The negative effects of alcohol It should be a surpr...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Alcohol Health Source Type: blogs
(University of Alabama at Birmingham) Doxorubicin is a chemotherapy drug used in ovarian, bladder, lung, thyroid and stomach cancers, but it carries a harmful side effect. The drug causes a dose-dependent heart toxicity that can lead to congestive heart failure. Researchers have found an important contributor to that heart pathology -- disruption of the metabolism that controls immune responses in the spleen and heart. This dysregulated immunometabolism impairs resolution of inflammation, and chronic, non-resolving inflammation leads to advanced heart failure.
Source: EurekAlert! - Biology - Category: Biology Source Type: news
(American College of Cardiology) Overall, heart failure is an uncommon complication of breast cancer treatment; however, the risk is higher in patients treated with certain types of chemotherapy and lower in younger patients, according to a study in a special 'Imaging in Cardio-oncology' issue of JACC: Cardiovascular Imaging. Researchers concluded that cardiac monitoring should be a higher priority for high-risk patients.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
AbstractCardio-oncology is a new field of interest in cardiology that focuses on the detection, monitoring, and treatment of cardiovascular disease occurring as a side effect of chemotherapy and radiotherapy. Both cancer treatment modalities can cause cardiac dysfunction, a major cause of morbidity and mortality in the oncologic population. It is necessary to periodically monitor cancer patients under treatment, especially those receiving anthracyclines and trastuzumab (monoclonal antibody), using mainly 3D echocardiography to calculate left ventricular ejection fraction and to estimate myocardial deformation. Additionally...
Source: Heart Failure Reviews - Category: Cardiology Source Type: research
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