Expression of autophagy related genes in chronic lymphocytic leukemia is associated with disease course

Chronic lymphocytic leukemia (CLL), the most common leukemia in the Western world, accounts for ∼40% of all adult leukemia. Though the pathogenesis of CLL is not entirely clear, accumulation of monoclonal CD5+/CD19+/CD23+ B lymphocytes is indicated mainly resulted from failure to undergo apoptosis rather than excessive proliferation [1]. There are a considerable number of patients with CLL w ho do not need treatment until treatment indications are present, while a proportion of patients have aggressive disease progression, which fully reflects the high degree of prognosis heterogeneity of CLL.
Source: Leukemia Research - Category: Hematology Authors: Tags: Research paper Source Type: research