Factors influencing the decision to share cancer genetic results among family members: an in ‐depth interview study of women in an Asian setting
CONCLUSIONSFacilitators and barriers for result‐sharing are similar to those among Western women. A framework to explain Asian patients' decision‐making process identifies optimal counselling opportunities to enhance communication with family.
Researchers from Uppsala University, Sweden, claim that for every one ovarian cancer case that is detected, five women are operated on, putting them at risk of pain, infection and blood loss.
CONCLUSIONS: KCNMA1-AS1 is overexpressed in EOC and negatively correlated with its prognosis. KCNMA1-AS1 participates in the occurrence and development of EOC by promoting proliferation, migration and inhibiting apoptosis of ovarian cancer cells via apoptosis pathway. PMID: 31210304 [PubMed - in process]
CONCLUSIONS: miR-99a suppressed the proliferation through AKT/mTOR signaling pathway and the invasion-mediated EMT in ovarian cancer. The newly identified miR-99a/HOXA1/AKT/mTOR axis provides novel insight into the pathogenesis of ovarian cancer. PMID: 31210292 [PubMed - in process]
CONCLUSIONS: LncRNA FAM83H-AS1 was a novel factor involved in OC progression. Our findings suggested that FAM83H-AS1 could serve as a potential biomarker and therapeutic target for OC. PMID: 31210291 [PubMed - in process]
CONCLUSIONS: We showed that PCAT-1 promotes the progression of ovarian cancer through enhancing cell metastasis and proliferation via suppressing KLF6, which might be a novel therapeutic strategy in ovarian cancer. PMID: 31210290 [PubMed - in process]
CONCLUSIONS: LINC00968 expression is markedly upregulated in EOC. Meanwhile, it arrests the cell cycle in the G1 phase by inhibiting the ERK and AKT pathways, thus accelerating EOC progression. PMID: 31210289 [PubMed - in process]
Conclusion: Agranulocytosis is a very rare adverse event of tamoxifen.Breast Care
Fewer than 5 percent of cancer patients participate in research that could improve care. Navigators could help patients find the right studies.
(Uppsala University) The majority of women who undergo surgery for suspected ovarian cancer do not have cancer. A novel blood test developed by researchers at Uppsala University and the Sahlgrenska Academy, University of Gothenburg, now offers the possibility of more precise diagnostics without the need for surgery. This could lead to a reduction in unnecessary surgery and to earlier detection and treatment for affected women. The study was recently published in Communications Biology.
ConclusionsOur study demonstrated the feasibility of efficiently identifying both CD4+ and CD8+ neoantigen-specific T-cells in EOC. Autologous lymphocytes genetically engineered with tumor antigen-specific TCR can be used to generate cells for use in the personalized adoptive T-cell transfer immunotherapy.