Impact of Auditory Integrative Training (AIT) on Transforming Growth Factor Beta 1 (TGF- β1) and Its Effect on Behavioural and Social Emotions in Children with Autism Spectrum Disorder (ASD)

Objective: To explore the impact of auditory integrative training (AIT) on inflammatory biomarker transforming growth factor- β1 (TGF-β1) and to assess its effect on social behaviours in children with autism spectrum disorder (ASD). Subjects and Methods: In this cross-sectional study 15 subjects (14 males, I female) with ASD aged 3-12 years were recruited. All subjects were screened for autism by Diagnostic and Statistic al Manual of Mental Disorders (DSM-IV). Plasma levels of TGF-β1 in all subjects were measured using sandwich enzyme immunoassay (ELISA) immediately after the AIT sessions and after 1 and 3 months. Pre-AIT and post-AIT behavioural scores were also calculated for each child using the Childhood Autism Rating Scale (CARS), Social Responsiveness Scale (SRS), and the Short Sensory Profile (SSP). Data was analysed using the Statistical Package for the Social Sciences (SPSS) computer program (SPSS 21.0 for Windows, Chicago, Illinois, USA). Results: Plasma levels of TGF-β1 significantly increased to 85% immediately (20.13±12, p
Source: Medical Principles and Practice - Category: Internal Medicine Source Type: research