Glucagon receptor structure offers new opportunities for type 2 diabetes drug discovery

(Chinese Academy of Sciences Headquarters) Recently, scientists at SIMM determined the crystal structure of GCGR in complex with a glucagon analogue and partial agonist NNC1702. This structure reveals, for the first time, the molecular details of a class B GPCR binding to its peptide ligand at high resolution and unexpectedly discloses the structural complexity that governs receptor activation, thereby greatly expanding the understanding of class B GPCR signal transduction.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news