Silent Myocardial Infarction Linked to Heart Failure Risk

Silent and clinically manifested MI both correlated with future risk of heart failure in adjusted models
Source: Pulmonary Medicine News - Doctors Lounge - Category: Respiratory Medicine Tags: Cardiology, Family Medicine, Geriatrics, Internal Medicine, Critical Care, Emergency Medicine, Nursing, Pathology, Pulmonology, Journal, Source Type: news

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ConclusionsIn patients with T2D and persistent microalbuminuria, u-KIM-1, but not u-NGAL, was an independent risk factor for decline in eGFR, CVE and all-cause mortality, and contributed significant discrimination for all-cause mortality, beyond traditional risk factors.
Source: Acta Diabetologica - Category: Endocrinology Source Type: research
ConclusionsUnilateral pulmonary edema is a completely reversible condition with good patient outcome if it is suspected early and treated early. Even in the absence of readily available echocardiogram skills, a clinical examination is of paramount importance in making a clinical decision in low-resource settings to reduce mortality.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
AbstractPoor homing of cells after transplantation is an unresolved common issue in cardiac cell therapies. To enhance stem cell homing, the ligand CXC motif chemokine 12 (CXCL12) and its specific receptor CXC receptor type 4 (CXCR4) have been employed as a system in this study to show that induced expression of the endogenous CXCR4 gene in mouse-induced pluripotent stem cells (iPSCs) improved the cell migration. Loci-specific epigenome editing in the form of CpG demethylation at CXCR4 promoter region of the mouse iPSCs was accomplished with CXCR4b-TAL-Tet1c, chimeric fusion proteins of the catalytic domain of ten-eleven t...
Source: Inflammation - Category: Allergy & Immunology Source Type: research
CONCLUSIONS: In our cohort, DSE had a low sensitivity but high NPV in predicting perioperative MACE post OLT. A similar trend was noted for DSE in predicting 1-year MACE post OLT. We reiterate the need of a better screening and risk stratification tool for OLT. PMID: 30088354 [PubMed - as supplied by publisher]
Source: Korean Circulation Journal - Category: Cardiology Tags: Korean Circ J Source Type: research
ConclusionIn the studied population, SCAD was more prevalent in middle-aged women. Despite the high prevalence of in-hospital re-infarction or during follow-up, the prognosis was good overall.ResumoIntroduçãoA disseção coronária espontânea (DCE) é uma causa infrequente de síndrome coronária aguda. O crescente reconhecimento e diagnóstico dessa entidade tem alertado os clínicos para a sua ocorrência. Porém, a fisiopatologia da DCE e o respetivo prognóstico ainda se encontram mal esclarecidos. O objetivo deste estudo foi investiga...
Source: Revista Portuguesa de Cardiologia - Category: Cardiology Source Type: research
Authors: Alagiakrishnan K, Mah D, Gyenes G Abstract INTRODUCTION: Cardiac rehabilitation program is an evidence-based intervention and established model of exercise delivery following myocardial infarction and heart failure. Although it forms an important part of recovery and helps to prevent future events and complications, there has been little focus on its potential cognitive benefits. Areas covered: Coronary artery disease and heart failure are common heart problems associated with significant morbidity and mortality, and cognitive decline is commonly seen in affected individuals. Cognitive impairment may influ...
Source: Expert Review of Cardiovascular Therapy - Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research
ConclusionsIn a rat HF model, optimal HR with regard to acute hemodynamic performance is shifted. While in ShO rats increased HR facilitates CO increase induced by PI, in HF rats such increase reduces CO, while HR reduction has beneficial effects. Thus besides reducing progression of HF, HR-reducing interventions also offer immediate hemodynamic benefits.
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
Publication date: 11–17 August 2018Source: The Lancet, Volume 392, Issue 10146Author(s): Araz Rawshani, Naveed Sattar, Stefan Franzén, Aidin Rawshani, Andrew T Hattersley, Ann-Marie Svensson, Björn Eliasson, Soffia GudbjörnsdottirSummaryBackgroundPeople with type 1 diabetes are at elevated risk of mortality and cardiovascular disease, yet current guidelines do not consider age of onset as an important risk stratifier. We aimed to examine how age at diagnosis of type 1 diabetes relates to excess mortality and cardiovascular risk.MethodsWe did a nationwide, register-based cohort study of individuals wi...
Source: The Lancet - Category: General Medicine Source Type: research
Abstract Heart-specific antibodies have been widely associated with myocardial infarction (MI). However, it remains unclear whether autoantibodies mediate disease progression or are a byproduct of cardiac injury. To disambiguate the role of immunoglobulins in MI, we characterized the development of ischemic heart failure (HF) in agammaglobulinemic mice (AID-/-μS-/-). While these animals can produce functional B-cells, they cannot synthesize secretory IgM (μS-/-) or perform immunoglobulin class-switching (AID-/-), leading to complete antibody deficiency. Agammaglobulinemia did not affect overall post-MI survi...
Source: American Journal of Physiology. Heart and Circulatory Physiology - Category: Physiology Authors: Tags: Am J Physiol Heart Circ Physiol Source Type: research
The lifetime risk of developing heart failure (HF) of a person aged over 40 years in the general population is estimated at 20% and, although therapies for HF are improving, once diagnosed 14% of patients die in the first six months. [1,2] The etiology of HF varies from country to country, although the majority of cases are attributed to hypertension and coronary artery disease. [3] As such, it is well understood that onset of HF is a common occurrence after clinically diagnosed myocardial infarction.
Source: Journal of Cardiac Failure - Category: Cardiology Authors: Source Type: research
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