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Invasive Aspergillosis in Heart Transplant Recipients

Invasive Aspergillosis in Heart Transplant RecipientsWed, 01/03/2018 - 12:08News blog
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news

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Abstract Invasive aspergillosis rarely involves the thoracic aorta and is associated with a poor prognosis. A 56-year-old heart transplant recipient presented with invasive aspergillosis, primary Aspergillus aortitis, and a ruptured thoracic aorta pseudoaneurysm. Open surgical repair was not possible because of severe sepsis. Therefore, a sequential surgical strategy was planned, including emergency thoracic endovascular aortic repair, followed by antifungal treatment and definitive open repair with explantation of the endograft and placement of a cryopreserved arterial allograft under extracorporeal membrane oxyg...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Ann Thorac Surg Source Type: research
Zaw Min, Manik Veer, Parth Rali, Anil Singh, Nitin BhanotLung India 2017 34(4):376-379Invasive aspergillosis generally occurs during the first 1–6 months after heart transplantation. It has been rarely seen in the first 2 weeks postcardiac transplant. We herein describe a unique case of invasive pulmonary aspergillosis (IPA) diagnosed on day 9 postorthotopic heart transplantation. The known risk factors for IPA in cardiac transplant recipients were not identified in our case. The organ recipients from the same donor did not report Aspergillus infection. Hospital environmental samplings failed to demonstrate Aspergill...
Source: Lung India - Category: Respiratory Medicine Authors: Source Type: research
We present a heart transplant patient who succumbed to drug resistant aspergillus pneumonia. Myocardial ischemic damage from aspergillus vasculitis was likely the final event.
Source: Human Pathology: Case Reports - Category: Pathology Source Type: research
Invasive aspergillosis is the most common invasive fungal infection in lung transplant recipients. The use of galactomannan testing in bronchoalveolar lavage (BAL) fluid has improved diagnosis of invasive aspergillosis; however, false-positive results can lead to overdiagnosis and unnecessary treatment. The use of proinflammatory markers such as pentraxin 3 (PTX3) may help differentiate between Aspergillus colonization and disease.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Original Clinical Science Source Type: research
Invasive aspergillosis is the most common invasive fungal infection in lung transplant recipients. The use of galactomannan testing in bronchoalveolar lavage fluid has improved the diagnosis of invasive aspergillosis; however, false positive results can lead to over diagnosis and unnecessary treatment. The use of proinflammatory markers, such as pentraxin 3, may help differentiate between Aspergillus colonization and disease.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
Galactomannan (GM) is the most sensitive and widely available biomarker for the diagnosis of invasive aspergillosis (IA) in bronchoalveolar lavage (BAL). The ability to detect GM in exhaled breath condensate (EBC) would be significantly less invasive for patients, but the performance of EBC GM levels is unknown. We measured GM values in EBC of lung transplant recipients (LTRs).
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
We present the case of a 61-year-old man suffering from invasive aspergillosis 2 months following heart transplantation. He was suffering from hypertrophic cardiomyopathy and he underwent orthotropic heart transplantation. He was readmitted to the Department of Cardiology 69 days following transplantation due to symptoms of productive cough for 5 days. It was accompanied by chest pain, shortness of breath, and fever up to 39°C. He was slightly cyanotic and confused on physical examination. The patient's status deteriorated within the following 2 days. On bronchoscopic specimen examinations Aspergillus mould filaments w...
Source: Polish Journal of Cardio-Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Tags: Kardiochir Torakochirurgia Pol Source Type: research
Publication date: Available online 24 February 2016 Source:Cor et Vasa Author(s): Július Godava, Jan Krejčí, Petr Hude, Eva Ozábalová, Tomáš Honek, Petr Němec, Michal Tichý, Marta Pažourková, Lenka Špinarová According to the ISHLT registry infectious complications are the leading cause of death in the first year after heart transplantation. Presented case report describes the fate of 63-year-old patient with heart failure due to coronary artery heart disease, which in March 2012, underwent a heart transplantation. In May comes with symptoms...
Source: Cor et Vasa - Category: Cardiology Source Type: research
We report on a case of a heart transplanted Caucasian man, who arrived at our hospital because of the onset of diplopy. We performed a broad diagnostic work-up: the brain MRI showed a single ring-enhancing thalamo-mesencephalic area suggestive of abscess lesion; cerebrospinal fluid (CSF) analysis disclosed galactomannan and beta-D-glucan antigens. Thus the antifungal therapy was immediately started. We decided to discontinue the therapy 16 months later because of severe hepatic toxicity, given that the patient was persistently asymptomatic, brain imaging showed a progressive resolution of the abscess area and CSF antigen a...
Source: Infezioni in Medicina - Category: Infectious Diseases Tags: Infez Med Source Type: research
Lung transplant recipients have a high incidence of pulmonary aspergillosis which is associated with high morbidity and mortality despite antifungal prophylaxis and treatment. Early diagnosis is associated with improved survival. Given the poor sensitivity of conventional mycological culture in respiratory samples, we determine the utility of novel Aspergillus antigen and PCR based diagnostic tests in a cohort of lung transplant recipients.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
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