Determinants and clinical implications of chromosomal instability in cancer

Determinants and clinical implications of chromosomal instability in cancerDeterminants and clinical implications of chromosomal instability in cancer, Published online: 03 January 2018; doi:10.1038/nrclinonc.2017.198Aberrant chromosomal architecture is one of the most common features of cancer and can often lead to chromosomal instability (CIN). In this Review, the authors describe the role of CIN in the development and progression of cancer and the potential to target the therapeutic vulnerabilities created by this process.
Source: Nature Clinical Practice Oncology - Category: Cancer & Oncology Authors: Source Type: research