Are Lethal Alleles Too Abundant in Humans?

Are Lethal Alleles Too Abundant in Humans? Trends Genet. 2017 Dec 28;: Authors: Ballinger MA, Noor MAF Abstract Across species, many individuals carry one or more recessive lethal alleles, posing an evolutionary conundrum for their persistence. Using a population genomic approach, Amorim et al. studied the abundance of lethal disease-causing mutations in humans and found that, while appearing more common than expected, most may nonetheless persist at frequencies predicted by mutation-selection balance. PMID: 29290402 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/29290402?dopt=Abstract

Source: Trends in Genetics : TIG - December 28, 2017 Category: Genetics & Stem Cells Authors: Ballinger MA, Noor MAF Tags: Trends Genet Source Type: research

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