Lung cancer screening works better when individual risk factors are taken into account, study says

New research estimates that in a single year, some 5,000 lung cancer deaths might be averted if some former smokers who don ’t currently qualify for lung-cancer screening were to get a computed tomography scan capable of detecting malignancy.The U.S. Preventive Services Task Force, which lays down...
Source: Los Angeles Times - Science - Category: Science Authors: Source Type: news

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Conclusions: The greatest impact of using the miRNAs panel CT scan was decreasing the false positive. miRNAs panel can improve the diagnosis of lung cancer presenting with nodules combined with CT. PMID: 30233883 [PubMed]
Source: Journal of Thoracic Disease - Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research
Conclusions: With contemporary staging techniques, so-called occult N2 disease, even with low volume and PET non-avid disease, does not have an indolent course and should still be considered a risk factor for poorer prognosis. PMID: 30233853 [PubMed]
Source: Journal of Thoracic Disease - Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research
Publication date: October 2018Source: The Annals of Thoracic Surgery, Volume 106, Issue 4Author(s): Seth B. Krantz, John A. Howington, Douglas E. Wood, Ki Wan Kim, Andrzej S. Kosinski, Morgan L. Cox, Sunghee Kim, Michael S. Mulligan, Farhood FarjahBackgroundPrior studies suggest underutilization of invasive mediastinal staging for lung cancer. We hypothesized that The Society of Thoracic Surgeons General Thoracic Surgery Database (STS-GTSD) participants would have higher rates of invasive staging compared with previous reports.MethodsWe conducted a retrospective cohort study (2012 to 2016) of lung cancer patients stag...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Physicians may soon use artificial intelligence (AI) and medical images to study tumors without a biopsy. The techniques developed to study tumors in this new way are described in the September 1 issue of The Lancet Oncology. Along with helping physicians learn more about tumors without surgery, the new approach should help identify which cancer patients will respond best to cutting-edge immunotherapy treatments. The AI techniques could be useful for “predicting clinical outcomes of patients treated with immunotherapy when validated by further prospective randomized trials,” the authors wrote. Immunotherapy tre...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
Journal of Medical Imaging and Radiation Oncology, EarlyView.
Source: Australasian Radiology - Category: Radiology Authors: Source Type: research
AbstractPurposeThe standard treatment for patients with stage III non-small cell lung cancer (NSCLC), unsuitable for resection and with good performance, is definitive radiotherapy with cisplatin-based chemotherapy. Our aim is to evaluate the effect of the maximum value of standardized uptake values (SUVmax) of the primary tumor in positron emission tomography-computed tomography (PET/CT) before treatment on complete response (CR) and overall survival.MethodsThe data of 73 stage III NSCLC patients treated with concurrent definitive chemoradiotherapy (CRT) between 2008 and 2017 and had PET/CT staging in the pretreatment per...
Source: Clinical and Translational Oncology - Category: Cancer & Oncology Source Type: research
Authors: Ma W, Wang M, Li X, Huang H, Zhu Y, Song X, Dai D, Xu W Abstract The aim of the present study was to investigate the prognostic value of quantitative [18F]fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) parameters for patients with non-small cell lung cancer (NSCLC). The present study conducted a retrospective review of the medical records of 203 patients with NSCLC, of which 193 patients underwent baseline 18F-FDG PET/CT prior to initial therapy. Multivariate analyses using Cox's proportional hazards regression were performed for the assessment of the association betwe...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Authors: Konert T, van de Kamer JB, Sonke JJ, Vogel WV Abstract Advancements in functional imaging technology have allowed new possibilities in contouring of target volumes, monitoring therapy, and predicting treatment outcome in non-small cell lung cancer (NSCLC). Consequently, the role of 18F-fluorodeoxyglucose positron emission tomography (FDG PET) has expanded in the last decades from a stand-alone diagnostic tool to a versatile instrument integrated with computed tomography (CT), with a prominent role in lung cancer radiotherapy. This review outlines the most recent literature on developments in FDG PET imagin...
Source: Journal of Thoracic Disease - Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research
Authors: Roach MC, Bradley JD, Robinson CG Abstract Radiation therapy is the foundation for treatment of locally advanced non-small cell lung cancer (NSCLC), a disease that is often inoperable and has limited long term survival. Local control of disease is strongly linked to patient survival and continues to be problematic despite continued attempts at changing the dose and fractionation of radiation delivered. Technological advancements such as 4-dimensional computed tomography (CT) based planning, positron emission tomography (PET) based target delineation, and daily image guidance have allowed for ever more accu...
Source: Journal of Thoracic Disease - Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research
Right now, the only patients who get a CT scan for early detection are people considered high risk, including current and former smokers. That ’s despite proof that 80% of new lung cancer patients have either never smoked or quit decades prior.
Source: Healthcare News - Category: Pharmaceuticals Authors: Source Type: news
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