Fractional Exhaled NO Moderately Accurate to Diagnose Asthma
FeNO measurement performs better in diagnosing non - smokers, children, and steroid - naive patients
Conditions: Asthma; Allergic Rhinitis; Allergic Conjunctivitis Interventions: Other: Active air purifier in respiratory allergies/asthma; Other: Sham air purifier Sponsor: Molekule Recruiting
Conclusion: OAS was the most common food allergy in birch pollen-sensitized patients. This study revealed the unique triggers of OAS in Korea in addition to well-known triggers. PMID: 30093847 [PubMed - in process]
Just 60% of low-income urban preschoolers with asthma have the medications they need available at home, new findings from the U.S. show.Reuters Health Information
Authors: Gotoh M, Kaminuma O, Hiroi T, Okubo K Abstract Sublingual immunotherapy (SLIT) is an effective treatment for allergic diseases. However, the mechanism by which this therapy exhibits its efficacy has not been fully delineated. To elucidate the mechanisms of SLIT in the treatment of cedar pollinosis (CP), we performed a multivariate analysis of microarray data on mRNA expression in CD4⁺ T cells and basophils. Although 2-year treatment with SLIT using cedar extracts was effective in>70% of patients with CP, the remaining patients did not respond to this therapy. The mRNA expression levels in peripheral C...
CONCLUSIONS: Our observations suggest that the Fas signaling pathway may be a common genetic risk factor for SCARs across multiple drugs. PMID: 30088374 [PubMed]
CONCLUSIONS: Our findings demonstrate a potential effect of Bc111b in controlling IL-17-mediated inflammation in asthma and suggest that Bc111b may be a useful therapeutic target for asthma. PMID: 30088373 [PubMed]
Authors: Kim BG, Lee PH, Lee SH, Baek AR, Park JS, Lee J, Park SW, Kim DJ, Park CS, Jang AS Abstract PURPOSE: The tight junction protein claudin-5 (CLDN5) is critical to the control of endothelial cellular polarity and pericellular permeability. The role of CLDN5 in chronic obstructive pulmonary disease (COPD) remains unclear. The aim of this study was to investigate the association between CLDN5 levels and clinical variables in patients with COPD. METHODS: In total, 30 patients with COPD and 30 healthy controls were enrolled in the study. The plasma CLDN5 level was checked in patients with stable or exacerbate...
CONCLUSIONS: We suggested the protective role of lactic acid bacteria in AD based on metagenomic analysis. Experimental findings further suggest that L. plantarum-derived EV could help prevent skin inflammation. PMID: 30088371 [PubMed]
CONCLUSIONS: Abdominal fat is associated with asthma, according to the location of fat accumulation. In asthmatic subjects, visceral fat seems to be attributable to the bronchial luminal narrowing, while subcutaneous fat may be related to thickening of bronchial wall. PMID: 30088370 [PubMed]
CONCLUSIONS: The CRS clinical scoring system from the JESREC study reflects an inflammatory endotype. However, the immunologic profile of mild ECRS was similar to that of non-ECRS. Therefore, we propose type 2-targeted medical treatment for moderate to severe ECRS and type 1/type 17-targeted for non-ECRS and mild ECRS as the first treatment option. PMID: 30088369 [PubMed]