Penn Vet's Boris Striepen receives $1.8m grant to fight deadly diarrheal disease in infants

(University of Pennsylvania) Boris Striepen, PhD, Professor of Pathobiology at the School of Veterinary Medicine at the University of Pennsylvania, has received a $1.8-million, three-year grant from the Bill&Melinda Gates Foundation to enable the development of drugs for cryptosporidiosis, a diarrheal disease caused by microscopic parasites.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news

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is AD Abstract Cryptosporidium is a genus of single celled parasites capable of infecting a wide range of animals including humans. Cryptosporidium species are members of the phylum apicomplexa, which includes well-known genera such as Plasmodium and Toxoplasma. Cryptosporidium parasites cause a severe gastro-intestinal disease known as cryptosporidiosis. They are one of the most common causes of childhood diarrhoea worldwide, and infection can have prolonged detrimental effects on the development of children, but also can be life threatening to HIV/AIDS patients and transplant recipients. A variety of hosts can a...
Source: Experimental Parasitology - Category: Parasitology Authors: Tags: Exp Parasitol Source Type: research
Publication date: Available online 12 November 2018Source: Veterinary ParasitologyAuthor(s): M.L. Tomazic, A.E. Rodriguez, J. Lombardelli, T. Poklepovich, C. Garro, R. Galarza, K. Tiranti, M. Florin-Christensen, L. SchnittgerAbstractThe apicomplexan protozoan Cryptosporidium parvum is an important causative agent of diarrhea of neonatal bovines. Vaccination has been proposed as an advantageous strategy against cryptosporidiosis of calves since besides protection against disease it has also the potential to prevent dissemination of the infective oocysts into the environment. Antigens anchored to the parasite surface via gly...
Source: Veterinary Parasitology - Category: Veterinary Research Source Type: research
Authors: Opoku YK, Boampong JN, Ayi I, Kwakye-Nuako G, Obiri-Yeboah D, Koranteng H, Ghartey-Kwansah G, Asare KK Abstract Objective: To identify the socio-behavioral risk factors associated with cryptosporidiosis among HIV/AIDS patients with chronic diarrhea symptoms visiting the HIV referral clinic at Cape Coast Teaching Hospital, Ghana. Methods: A cross-sectional study was conducted among 50 HIV/AIDS patients with recurrent diarrhea. Questionnaires were administered to collect social and behavioral risk factors associated with Cryptosporidium and other opportunistic protozoan parasitic infections in HIV patien...
Source: Open AIDS Journal - Category: Infectious Diseases Tags: Open AIDS J Source Type: research
Publication date: Available online 13 October 2018Source: Spatial and Spatio-temporal EpidemiologyAuthor(s): N.F. Reeve, P.J. Diggle, K. Lamden, T. KeeganAbstractGiardia and Cryptosporidium are both waterborne parasites and leading causes of gastroenteritis. Although specimens from diarrhoeic patients are routinely examined for Cryptosporidium, they are often not examined for Giardia so many cases go undiagnosed. Since 2002, all faecal specimens in Central Lancashire have been tested for infection with Giardia and Cryptosporidium. The aim of this paper is to gain insight into the factors contributing to giardiasis and cryp...
Source: Spatial and Spatio-temporal Epidemiology - Category: Epidemiology Source Type: research
This study aimed to establish an experimental infection of Cryptodporidium canis in canids. Infectivity and pathogenicity have been measured by evaluating the clinical status, pattern of oocyst excretion and histological examination. Results showed that C. canis was not infective for immunocompetent dogs or mice with severe combined immunodeficiency syndrome (SCID). Oocysts were first detected in the feces of immunosuppressed dogs on day 3 post-infection (p.i.), with levels peaking twice on days 10 and 17 p.i. during the patent period. cryptosporidial developmental stages were found in the duodenum and jejunum of dogs in h...
Source: Experimental Parasitology - Category: Parasitology Authors: Tags: Exp Parasitol Source Type: research
ou KT Abstract Cryptosporidiosis is a zoonotic disease caused by species in the genus Cryptosporidium. In young ruminants, Cryptosporidium parvum causes economically significant disease with mild to severe clinical signs and occasional death. The typical clinical course in animals aged 1 to 3 weeks old is acute diarrhoea. Currently there are no available treatments that are fully effective against cryptosporidiosis in either humans or animals. Therefore there is a critical need for the development of new therapeutic agents. We adapted two in vitro culture systems (HCT-8 and Caco-2 cell lines) for C. parvum infecti...
Source: Experimental Parasitology - Category: Parasitology Authors: Tags: Exp Parasitol Source Type: research
This study will be helpful for experimental validation. PMID: 30240985 [PubMed - as supplied by publisher]
Source: Computational Biology and Chemistry - Category: Bioinformatics Authors: Tags: Comput Biol Chem Source Type: research
[Cryptosporidiosis and "One Health"]. Rev Salud Publica (Bogota). 2018 Jan-Feb;20(1):138-143 Authors: Hernández-Gallo N, Hernández-Flórez LJ, Cortés-Vecino JA Abstract Cryptosporidiosis is a diarrheal disease (zoonotic) caused by the parasite Cryptosporidium, which infects the intestine. It occurs in humans and in different pets, farm and wild animals. Its role is underestimated and little is known about its epidemiology, due to the low interest it draws and the limited availability of diagnostic methods. The population health, both human and animal, is related to ...
Source: Revista de Salud Publica - Category: International Medicine & Public Health Tags: Rev Salud Publica (Bogota) Source Type: research
AbstractPurpose of ReviewCryptosporidium is an intestinal apicomplexan recently classified as a gregarine. It is associated with diarrhea both in immunocompromised and immunocompetent patients. Direct person-to-person, zoonotic, and waterborne are the principal transmission routes. Despite the significant impact on public health of cryptosporidiosis, especially in developing countries, there are few studies on this parasitic disease. This systematic review will focus on the cryptosporidiosis situation in Colombia, describing the prevalence data on humans, other animals, and environmental sources. Species and subtypes, risk...
Source: Current Tropical Medicine Reports - Category: Tropical Medicine Source Type: research
(American Society for Microbiology) In an unexpected research finding infections with the intestinal parasite, Cryptosporidium parvum, worsened in mice that had been given a probiotic. The research was published in Applied and Environmental Microbiology, a journal of the American Society for Microbiology.
Source: EurekAlert! - Biology - Category: Biology Source Type: news
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