Scriptaid inhibits cell survival, cell cycle and promotes apoptosis in multiple myeloma via epigenetic regulation of p21

• HDAC inhibitor Scriptaid inhibits MM cell proliferation and cell cycle.• Scriptaid induces MM cell apoptosis.• p21 is the key regulator of Scriptaid-mediated cell death.• Scriptaid activates p21 transcription by increasing H3Ac level at its promoter.

Source: Experimental Hematology - January 2, 2018 Category: Hematology Authors: Ruosi Yao, Danyang Han, Xiaoyang Sun, Yu Xie, Qingyun Wu, Chunling Fu, Yao Yao, Hujun Li, Zhenyu Li, Kailin Xu Source Type: research