Researchers advocate for safer alternative to paint stripper chemical
An alternative to a potentially deadly chemical found in common paint strippers faces hurdles to reach consumers. Dozens of people who used methylene chloride died. Last month, the EPA indefinitely postponed a ban on that chemical, proposed by the Obama administration. Anna Werner spoke to researchers who developed what they call a less-harmful product.
Authors: Masouris I, Klein M, Ködel U Abstract INTRODUCTION: Central nervous system (CNS) infections can be life-threatening and are often associated with disabling sequelae. One important factor in most CNS infections is a timely pathogen-specific treatment. The diagnostic methods available, however, do not always reach a satisfying sensitivity and specificity. In these cases, there is need for additional diagnostic biomarkers. Chemokines represent potential candidates as biomarkers, since they are an important pillar of the host immune response. The aim of this review is to discuss the diagnostic potential o...
Publication date: Available online 1 June 2020Source: Biotechnology ReportsAuthor(s): Bouchra Louasté, Noureddine Eloutassi
Publication date: Available online 1 June 2020Source: Biocatalysis and Agricultural BiotechnologyAuthor(s): S.R. Saranya, Sudhakaran R
Publication date: Available online 1 June 2020Source: Biocatalysis and Agricultural BiotechnologyAuthor(s): Jee Yin Cheong, Mustafa Muskhazli, Abd Aziz Nor Azwady, Siti Aqlima Ahmad, Azleen Ahmad Adli
OHSU clinicians want to get the word out that it's safe to come in for care.
Discussion and conclusions: M. sirikitiae is a source of cytotoxic lignans and alkaloids. Among the cytotoxic compounds, magnone A and 6-methoxymarcanine A are potentially useful lead compounds for the further development of anticancer agents because of their selective inhibitory effects on cancer cell lines. PMID: 32478640 [PubMed - as supplied by publisher]
Discussion and conclusions: EXD demonstrated neuroprotective effects and improved depression-like behaviour in mice. Further research should be focussed on the mechanism of the active components in EXD. PMID: 32476554 [PubMed - in process]
This study examined the antihypoxia effects of SPM in vivo.Materials and methods: The dried and pulverised of SPM was extracted from root crude drug with 70% ethanol with ultrasound. Male Sprague-Dawley rats were divided into three groups (n = 10): normal group, hypoxia group (altitude of 4260 m), and hypoxia + SPM group (altitude of 4260 m, SPM of 1.0 g/kg/day). The experiment persisted for 4 weeks. The mean pulmonary arterial pressure (mPAP), hypoxia-inducible factor-1α (HIF-1α) mRNA, and lung pathology were analysed using pulmonary artery pressure recorde...
Authors: Qian X, Wang Z, Ning J, Qin C, Gao L, He N, Lin D, Zhou Z, Li G Abstract Context: Persimmon tannin (extract of Diospyros kaki L.f [Ebenaceae]) and Aloe gel (extract of Aloe vera (L.) Burm.f. [Asphodelaceae]) are known as anti-radiation agents. However, radiation resistance of the persimmon tannin-Aloe gel composite remains inconclusive.Objective: To investigate the capacity of the persimmon tannin-Aloe gel composite to protect against ionising radiation at the cellular level.Materials and methods: HaCaT (human epidermal keratinocytes) cells were pre-treated with PT-A-1 (the mass ratio of persimmon tannin a...
Conclusion: These results show PSD, R13, and PSA are good candidates as natural products for use in the treatment of lung cancer. Potential signalling pathways and protein targets need to be further validated. The application of the drug combination approach also provides a therapeutic strategy for cancer. PMID: 32476531 [PubMed - in process]