RING-finger protein 6 amplification activates JAK/STAT3 pathway by modifying SHP-1 ubiquitylation and associates with poor outcome in colorectal cancer.

Conclusions Genomic amplification drives RNF6 overexpression in CRC. RNF6 may be a novel biomarker in colorectal carcinogenesis, and RNF6 may increase pSTAT3 level via promoting SHP-1 ubiquitylation and degradation. Targeting the RNF6/SHP-1/STAT3 axis provides a potential therapeutic option for RNF6-amplified tumors.
PMID: 29288235 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - December 29, 2017 Category: Cancer & Oncology Authors: Liang Q, Ma D, Zhu X, Wang Z, Sun TT, Shen C, Yan T, Tian X, Yu T, Guo F, Tang J, Lin Y, Chen H, Zhou C, Ge Z, Zhong M, Chen J, Liu Q, Wang Z, Fang JY, Chen HY, Hong J Tags: Clin Cancer Res Source Type: research