Role of Innate Immunity in the Pathogenesis of Type 1 and Type 2 Diabetes.

Role of Innate Immunity in the Pathogenesis of Type 1 and Type 2 Diabetes. J Korean Med Sci. 2014 Aug;29(8):1038-1041 Authors: Lee MS Abstract The importance of innate immunity in host defense is becoming clear after discovery of innate immune receptors such as Toll-like receptor or Nod-like receptor. Innate immune system plays an important role in diverse pathological situations such as autoimmune diseases. Role of innate immunity in the pathogenesis of metabolic disorders such as type 2 diabetes, metabolic syndrome or atherosclerosis that has not been previously considered as inflammatory disorders, is also being appreciated. Here, the role of innate immunity in the development of type 1 diabetes, a classical organ-specific autoimmune disease, and type 2 diabetes will be discussed, focusing on the role of specific innate immune receptors involved in these disease processes. GRAPHICAL ABSTRACT: PMID: 25120311 [PubMed - as supplied by publisher]
Source: J Korean Med Sci - Category: Journals (General) Authors: Tags: J Korean Med Sci Source Type: research