Berry gives boost to cervical cancer therapy

According to the Centers for Disease Control and Prevention, approximately 12,000 women in the United States are diagnosed with cervical cancer each year. One of the most common treatments for cervical cancer is radiation. While radiation therapy destroys cancer cells, it also destroys nearby healthy cells. University of Missouri School of Medicine researchers studied in vitro human cancer cells to show that combining blueberry extract with radiation can increase the treatment's effectiveness.
Source: World Pharma News - Category: Pharmaceuticals Tags: Featured Research Research and Development Source Type: news

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This study evaluated the integration and methlyation of human papillomavirus type 16 (HPV16) in head and neck squamous cell carcinoma (HNSCC) and its oral precursor, high-grade oral epithelial dysplasia (hgOED). Archival samples of HPV16-positive hgOED (N = 19) and HNSCC (N = 15) were evaluated, along with three HNSCC (UMSCC-1, -47 and -104) and two cervical cancer (SiHa and CaSki) cell lines. HgOED cases were stratified into three groups with increasing degrees of cytologic changes (mitosis, karyorrhexis and apoptosis). The viral load was higher and the E2/E6 ratio lower (indicating a greater tendency toward viral integra...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Authors: Reid E, Suneja G, Ambinder RF, Ard K, Baiocchi R, Barta SK, Carchman E, Cohen A, Gupta N, Johung KL, Klopp A, LaCasce AS, Lin C, Makarova-Rusher OV, Mehta A, Menon MP, Morgan D, Nathwani N, Noy A, Palella F, Ratner L, Rizza S, Rudek MA, Taylor J, Tomlinson B, Wang CJ, Dwyer MA, Freedman-Cass DA Abstract People living with HIV (PLWH) are diagnosed with cancer at an increased rate over the general population and generally have a higher mortality due to delayed diagnoses, advanced cancer stage, comorbidities, immunosuppression, and cancer treatment disparities. Lack of guidelines and provider education has le...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research
Kai Niu, Yunming Yao, Ming Xiu, Chunjie Guo, Yuanyuan Ge, Jianmeng Wang
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
ConclusionsWe did not find statistical relationship between HT and the clinical factors of age>50 years and DM. Statistical relationship for the dosimetric factors V10 > 90% and V20 > 80% was not found as well. On the contrary, obesity, epidermoid histology and ≥IIIA CS, showed statistical significance for development of HT ≥grade 2.
Source: Reports of Practical Oncology and Radiotherapy - Category: Cancer & Oncology Source Type: research
ConclusionsTreatment with EBRT or IB does not appear to impair sexual function in women with gynecologic cancer. Age less than 50, concurrent chemotherapy, and cervical cancer may place women with gynecologic cancer at higher risk for decreased sexual function following radiation.
Source: Reports of Practical Oncology and Radiotherapy - Category: Cancer & Oncology Source Type: research
Publication date: Available online 13 August 2018Source: Journal of Molecular StructureAuthor(s): Syarmila Ishak, Guan-Yeow Yeap, Shanmugapriya, Sreenivasan Sasidharan, Masato M. ItoAbstractA new fluorene derivative, 1,1’-(9,9-dihexyl-9H-fluorene-2,7-diyl)bis (N,N-bis(pyridine-2-ylmethyl)methanamine has been successfully synthesized through condensation reaction of bis(2-pyridylmethyl)amine and 2,7-bis(bromomethyl)-9,9-dihexyl-9H-fluorene with exceptionally good yield (60%). The molecular structure of the synthesized compound was well characterized by nuclear magnetic resonance (NMR), infrared (FTIR), UV–vis ab...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Publication date: Available online 13 August 2018Source: Journal of Molecular StructureAuthor(s): Sunil K. Pandey, Seema Pratap, Manish K. Tiwari, Gaetano Marverti, Jerry P. JasinskiAbstractTwo new compounds N-(2-chloro-4-nitrophenyl)-N'-(phenoxycarbonyl) thiocarbamide (1) and N-(2-chloro-4-nitrophenyl)-N'-(4-nitrobenzoyl) thiocarbamide (2), have been derived by the reaction of phenoxycarbonyl isothiocyanate/4-nitrobenzoyl isothiocyanate with 2-chloro-4-nitroaniline. The structures of these compounds were determined by spectroscopic (FT-IR, 1H and 13C NMR, UV–Visible) and single crystal X-ray studies. Both the crysta...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Hologic (NSDQ:HOLX), known in the medtech industry for its mammography and diagnostics devices, is rethinking what it means to be a women’s healthcare company. The 6,000-person company wants to expand its reach to include products that care for women’s well-being, as well as their health – a concept that Dr. Edward Evantash honed when he led the Ob/Gyn division at Tufts Medical Center. “The beauty of being an Ob/Gyn is that you really take care of women throughout the continuum of their lifecycle,” Evantash, Hologic’s medical director &VP of global medical affairs, told MassDevi...
Source: Mass Device - Category: Medical Devices Authors: Tags: Business/Financial News Food & Drug Administration (FDA) Women's Health Cynosure Inc. Hologic Source Type: news
Journal of Magnetic Resonance Imaging, EarlyView.
Source: Journal of Magnetic Resonance Imaging - Category: Radiology Authors: Source Type: research
The objective of this review is to present insights into pharmacotherapeutic techniques, which can be used for transdermal delivery of anticancer agents through skin due to its potential to create a new frontier in treatment of cancer. PMID: 30095010 [PubMed - as supplied by publisher]
Source: Artificial Cells, Nanomedicine and Biotechnology - Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research
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