Effects of Higher Quality of Care in CKD and Diabetes Effects of Higher Quality of Care in CKD and Diabetes
What are the associations between improved quality of care and outcomes for patients with diabetes-related chronic kidney disease?American Journal of Kidney Diseases
The epidemic of obesity parallels that of chronic kidney disease (CKD). Obesity worsens the course of CKD mainly defined by an abnormal glomerular filtration rate (GFR). Patients with severe obesity stages (II and III with body mass index, BMI>35 kg/m2) are eligible for bariatric surgery (BS), which is the most efficient method of achieving durable weight loss. BS may reverse glomerular hyperfiltration, albuminuria, improve adipocytokine profile, and relieve diabetes and hypertension. Obesity remission following BS might prevent the progression of renal failure in populations with morbid obesity.
Publication date: December 2018 Source:Value in Health Regional Issues, Volume 17 Author(s): Ramiro E. Gilardino, Eduardo González-Pier, Claudia Brabata End-stage renal disease, the last and most severe stage of chronic kidney disease, represents a major and rising concern for countries in Latin America, driven in large part by aging populations and the near-epidemic rises in diabetes, obesity, and hypertension. This places a great clinical, economic, and social burden on the region’s health systems. During the ISPOR 6th Latin America Conference held in Sao Paulo, Brazil, in September 2017, an educational for...
CONCLUSION: The data contradicted national studies reporting primary hypertension as the main cause of chronic kidney disease (CKD). A high rate of unknown causes and categorization bias were observed mainly in relation to primary hypertension as a cause of CKD, which affects the overall prevalence of causes of ESRD in patients on dialysis. PMID: 29782632 [PubMed - as supplied by publisher]
In this study, we discuss dialysis in the final phase of life and present a systematic way to address this dilemma. PMID: 29782631 [PubMed - as supplied by publisher]
Gestational diabetes may predispose women to early-stage kidney damage, a precursor to chronic kidney disease, according to US researchers.
CONCLUSIONS Anemia was more common in diabetic CKD patients. Diabetes mellitus was independently associated with iron deficiency. Surprisingly, diminished iron availability was not more frequent in diabetic patients. The physio-pathological mechanisms that could explain these findings remain to be elucidated.
Gestational diabetes occurs only in pregnancy and results when the level of blood sugar is too high.
FDA Approves Lokelma for Hyperkalemia The US Food and Drug Administration (FDA) has approved sodium zirconium cyclosilicate (Lokelma, AstraZeneca) — a medication that rapidly restores normal potassium levels — for adults with hyperkalemia. Formerly known as ZS-9, the drug is a “highly-selective, oral potassium-removing agent,” the company explains in a company news release. Hyperkalemia has become a significant problem. With more type 2 Diabetes Mellitus, we are seeing an explosion of chronic kidney disease. In patients with CKD 3b and 4, patients often develop hyporenin, hypoaldosterone...
Environmental factors drive epigenetic programming. DNA methylation is the best studied modification transmitting epigenetic information. A study by Qiu et al. examined potential epigenetic roots for the decline of renal function in Pima Indians. A genomewide survey of blood leukocytes uncovered differentially methylated DNA sites in regulatory regions of genes associated with chronic kidney disease. This longitudinal study provides the first clues o n epigenetic links between environmental factors and a high prevalence of diabetic kidney disease in Pima Indians.
(NIH/Eunice Kennedy Shriver National Institute of Child Health and Human Development) Gestational diabetes may predispose women to early-stage kidney damage, a precursor to chronic kidney disease, according to a study by researchers at the National Institutes of Health and other institutions. The study appears in Diabetes Care.