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Effects of Higher Quality of Care in CKD and Diabetes Effects of Higher Quality of Care in CKD and Diabetes

What are the associations between improved quality of care and outcomes for patients with diabetes-related chronic kidney disease?American Journal of Kidney Diseases
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Nephrology Journal Article Source Type: news

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PGC-1α ameliorates kidney fibrosis in mice with diabetic kidney disease through an antioxidative mechanism. Mol Med Rep. 2018 Jan 16;: Authors: Zhang L, Liu J, Zhou F, Wang W, Chen N Abstract The production of reactive oxygen species (ROS) is a common phenomenon in podocyte impairment, which leads to the irreversible progression of chronic kidney diseases, such as diabetic kidney disease (DKD). Previous research has indicated that peroxisome proliferator‑activated receptor γ (PPARγ) coactivator‑1α (PGC‑1α) participates in mitochondrial biogenesis and energy metabolis...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Chronic kidney disease (CKD) affects a substantial minority of people with type 2 diabetes (T2D). Analysis of US National Health and Nutrition Examination Survey (NHANES) datasets from 2007 through 2012 showed Stage 3 or worse disease (estimated glomerular filtration rate [eGFR]
Source: Journal of Diabetes - Category: Endocrinology Authors: Tags: Editorial Source Type: research
This study examined 3913 participants across the two trial arms who were not using insulin at baseline.Main MeasuresWe used Cox proportional hazards models to estimate the association between participant characteristics and time to insulin initiation. We performed time-varying adjustment for HbA1c measured eight times over the 10-year study period, as well as for multiple clinical and socioeconomic factors.Key ResultsA total of 1087 participants (27.8%) initiated insulin during a median follow-up of 8.0  years. Age was inversely associated with insulin initiation (adjusted hazard ratio [aHR] 0.88 per 10 years,P&t...
Source: Journal of General Internal Medicine - Category: Internal Medicine Source Type: research
Conclusions: Bardoxolone methyl preserves kidney function and may delay the onset of ESRD in patients with T2D and stage 4 CKD.Am J Nephrol 2018;47:40 –47
Source: American Journal of Nephrology - Category: Neurology Source Type: research
Objectives: As data on chronic kidney disease (CKD) incidence among Asian HIV patients has been limited, the present study aimed to estimate the CKD incidence in HIV-infected patients who received standard antiretroviral therapy in Thailand and to compare baseline demographics and clinical characteristics of the patients who developed CKD with those who do not. Design: A multicenter, observational prospective cohort of HIV patients with normal kidney functions who received standard antiretroviral therapy. Methods: CKD was diagnosed based on the KDIGO 2012 criteria, using Chronic Kidney Disease Epidemiology Collabor...
Source: AIDS - Category: Infectious Diseases Tags: Epidemiology and Social: Concise Communication Source Type: research
Abstract AimTo identify risk factors for acute kidney injury following major orthopaedic surgery. MethodsWe included all patients undergoing major orthopaedic surgery at University Hospital Geelong between 2008 and 2014 in the study. Out of 2188 surgeries audited, we identified cases of acute kidney injury using the RIFLE criteria and matched those to controls 2:1 for age, sex, procedure and chronic kidney disease stage. We reviewed their records for risk factors of postoperative acute kidney injury, including medications such as gentamicin, diuretics, non‐steroidal anti‐inflammatory drugs and angiotensin‐converting ...
Source: Nephrology - Category: Urology & Nephrology Authors: Tags: Original Article Source Type: research
Older patients with depression may be at greater risk of death following a procedure to replace a damaged aortic valve of the heart, reports astudy published today inJAMA Cardiology.“The clinical implications of our findings support active screening for depression before and after aortic valve procedures to identify patients who may benefit from further psychiatric evaluation for the diagnosis and treatment of a depressive disorder,” wrote Jonathan Afilalo, M.D., M.Sc., of Jewish General Hospital, Montreal, and colleagues.The study included patients who were at least 70 years of age with symptomatic aortic sten...
Source: Psychiatr News - Category: Psychiatry Tags: aortic stenosis aortic valve replacement cerebrovascular disease COPD depression diabetes Geriatric Depression Scale Short Form hypertension Jonathan Afilalo kidney disease Source Type: research
Population of patients with the impaired kidney function grows around the world. With the advances of the contemporary medicine people live to the older age, survive cardiac and cerebrovascular events, recover from the complex surgeries, overcome malignancies, infections and autoimmune diseases. That all frequently leads to the development of variable degree of chronic kidney impairment in form of interstitial and/or glomerular injury. Patients with chronic kidney disease (CKD) often share risk factors of hypertension, poorly controlled diabetes mellitus, arterial and venous vascular disease, obesity, malnutrition and chro...
Source: Journal of the American College of Certified Wound Specialists - Category: Dermatology Authors: Source Type: research
Publication date: February 2018 Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 125, Issue 2 Author(s): John J. Frazier, Regina Casian, Byron W. Benson Mönckeberg medial calcinosis describes calcifications affecting only the tunica media of medium-sized arteries. The entity is strongly associated with chronic kidney disease and diabetes mellitus. Radiographically, medial calcinosis presents as areas of linear calcifications in soft tissue; the linear calcifications are referred to as “tram tracks,” “pipe stem,” “rail tracking,” or “tram line&rdqu...
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
This study aimed to assess the association between frailty and bone loss in patients undergoing hemodialysis. This cross-sectional study included 214 (90 women, 124 men) Japanese outpatients undergoing maintenance hemodialysis three times per week, with a mean age of 67.1  years (women) and 66.8 years (men). Frailty was defined based on criteria set forth by the Cardiovascular Health Study (CHS)—19 (21.1%) women and 47 (37.9%) men were robust, 41 (45.6%) women and 43 (34.7%) men were pre-frail, and 30 (33.3%) women and 34 (27.4%) men were frail. For bone mass, qu antitative ultrasound (QUS) parameters (spee...
Source: Journal of Bone and Mineral Metabolism - Category: Orthopaedics Source Type: research
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