MicroRNAs: small molecules with big roles in neurodevelopment and diseases.

MicroRNAs: small molecules with big roles in neurodevelopment and diseases.
Exp Neurol. 2014 Aug 12;
Authors: Sun E, Shi Y
Abstract
MicroRNAs (miRNAs) are single-stranded, non-coding RNA molecules that play important roles in the development and functions of the brain. Extensive studies have revealed critical roles for miRNAs in brain development and function. Dysregulation or altered expression of miRNAs is associated with abnormal brain development and pathogenesis of neurodevelopmental diseases. This review serves to highlight the versatile roles of these small RNA molecules in normal brain development and their association with neurodevelopmental disorders, in particular, two closely related neuropsychiatric disorders of neurodevelopmental origin, schizophrenia and bipolar disorder.
PMID: 25128264 [PubMed - as supplied by publisher]

Source: Experimental Neurology - August 12, 2014 Category: Neurology Authors: Sun E, Shi Y Tags: Exp Neurol Source Type: research