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Scientists a step closer to mimicking way human body creates sperm

Researchers pass milestone on developmental path from stem cells to immature sperm, and hint lab-made sperm and eggs may one day be possibleScientists have come a step closer to mimicking the natural process by which the body creates sperm from stem cells in work that could ultimately provide new treatments for infertility.Speaking at theProgress Educational Trust annual conference in London this month, Azim Surani, director of germline and epigenetics research at the University of Cambridge ’s Gurdon Institute, said he and colleagues had passed a significant milestone on the path to producing sperm in the laboratory. The team is thought to be the first to have reached the halfway point on the developmental path from human stem cells to immature sperm.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Reproduction Stem cells Science Biology Fertility problems Health Society Medical research Source Type: news

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Abstract Krüppel-like zinc finger proteins form one of the largest families of transcription factors. They function as key regulators of embryonic development and a wide range of other physiological processes, and are implicated in a variety of pathologies. GLI-similar 1-3 (GLIS1-3) constitute a subfamily of Krüppel-like zinc finger proteins that act either as activators or repressors of gene transcription. GLIS3 plays a critical role in the regulation of multiple biological processes and is a key regulator of pancreatic β cell generation and maturation, insulin gene expression, thyroid hormone bios...
Source: Cellular and Molecular Life Sciences : CMLS - Category: Cytology Authors: Tags: Cell Mol Life Sci Source Type: research
In this study, we reported a comprehensive genome-wide DNA methylation landscape in chicken germ cells, and transcriptomic dynamics was also presented. By uncovering DNA methylation patterns on individual genes, some genes accurately modulated by DNA methylation were found to be associated with cancers and virus infection, e.g., AKT1 and CTNNB1. Chicken-unique markers were also discovered for identifying male germ cells. Importantly, integrated epigenetic mechanisms were explored during male germ cell differentiation, which provides deep insight into the epigenetic processes associated with male germ cell differentiation a...
Source: Stem Cell Reports - Category: Stem Cells Source Type: research
Conclusions: The differential adhesion method provides a more feasible approach and is an easier procedure to establish FGSC lines than traditional methods. The AKT pathway plays an important role in regulation of the proliferation and maintenance of FGSCs. These findings could help promote stem cell studies and provide a better understanding of causes of ovarian infertility, thereby providing potential treatments for infertility.Cell Physiol Biochem 2018;46:2114 –2126
Source: Cellular Physiology and Biochemistry - Category: Cytology Source Type: research
Stem cells have the remarkable potential to develop into many different cell types. Now, using mouse stem cells instead of the usual sperm and egg, scientists have created a structure like a blastocyst -- an early embryo.
Source: CNN.com - Health - Category: Consumer Health News Source Type: news
Abstract Understanding the genetic underpinning of early human development is of great interest not only for basic developmental and stem cell biology but also for regenerative medicine, infertility treatments, and better understanding the causes of congenital disease. Our current knowledge has mainly been generated with the use of laboratory animals, especially the mouse. While human and mouse early development present morphological resemblance, we know that the timing of the events as well as the cellular and genetic mechanisms that control fundamental processes are distinct between the species. The rapid techno...
Source: Current Opinion in Genetics and Development - Category: Genetics & Stem Cells Authors: Tags: Curr Opin Genet Dev Source Type: research
PMID: 29710348 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - Category: Internal Medicine Authors: Tags: Ann Intern Med Source Type: research
Amer J Perinatol DOI: 10.1055/s-0038-1646948Stem cells are a population of undifferentiated cells that originated from embryonic and fetal stages of development. Stem cells possess the potency to produce cells that ultimately form different tissues and organs. They are considered as potential alternative novel therapeutic agents for patients suffering from infertility due to their unlimited source and high differentiation potency. There are several studies that have shown that different types of stem cells (mesenchymal stem cells, embryonic, endometrial, and ovarian stem cells) can be differentiated into both spermatozoa a...
Source: American Journal of Perinatology - Category: Perinatology & Neonatology Authors: Tags: Review Article Source Type: research
(University of Maryland) A UMD researcher uncovered new mechanisms that dictate the development of germline stem cells. Mechanisms were found to be associated with genes responsible for cancers and viral infections among other major diseases. Markers used to identify male germ cells were discovered, exploring how environmental factors or epigenetics affect these cells and providing significant insight into treatments for male infertility. Findings set the stage for chickens as a more prominent model organism for stem cell research.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
A new study in the journal Nature Cell Biology has uncovered information about a key stage that human embryonic cells must pass through just before an embryo implants. The research, led by UCLA biologist Amander Clark, could help explain certain causes of infertility and spontaneous miscarriage.Infertility affects around 10 percent of the U.S. population, and roughly 15 to 20 percent of all pregnancies in the U.S. end in miscarriage. In many cases, the causes of infertility and miscarriage are unknown.A team led by Clark, a UCLA professor of molecular cell and developmental biology and member of the  Eli and Edythe Br...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
Journal of Cellular Physiology, EarlyView.
Source: Journal of Cellular Physiology - Category: Cytology Authors: Source Type: research
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