Registration of whole immunohistochemical slide images: an efficient way to characterize biomarker colocalization.

CONCLUSIONS: The method proposed in this work enables accurate registration (on the scale of a few cells) of virtual slides of adjacent tissue sections on which the expression of different proteins is evidenced by standard IHC. Furthermore, combining our method with a sequential labeling and erasing technique enables cell-scale colocalization.
PMID: 25125687 [PubMed - as supplied by publisher]

Source: Journal of the American Medical Informatics Association - August 14, 2014 Category: Information Technology Authors: Moles Lopez X, Barbot P, Van Eycke YR, Verset L, Trépant AL, Larbanoix L, Salmon I, Decaestecker C Tags: J Am Med Inform Assoc Source Type: research