Annals of Internal Medicine tip sheet for Aug. 19, 2014

(American College of Physicians) The Aug. 19 issue of Annals of Internal Medicine contains the following articles: 'Opinion: Ebola-stricken American volunteers deserve special treatment'; 'Opinion: Ebola virus highly unlikely to spread in US'; 'Longer life expected for children born and diagnosed with cystic fibrosis in 2010'; and 'Atypical antipsychotic drug use increases risk for acute kidney injury.'
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news

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Abstract Pathogenic variants in the Cystic Fibrosis Transmembrane Conductance Regulator gene (CFTR) are responsible for cystic fibrosis (CF), the commonest monogenic autosomal recessive disease, and CFTR-related disorders in infants and youth. Diagnosis of such diseases relies on clinical, functional, and molecular studies. To date, over 2,000 variants have been described on CFTR (~40% missense). Since few of them have confirmed pathogenicity, in silico analysis could help molecular diagnosis and genetic counseling. Here, the pathogenicity of 779 CFTR missense variants was predicted by consensus predictor PredictSNP and co...
Source: Genetics and Molecular Biology - Category: Genetics & Stem Cells Source Type: research
Merck's Ebola vaccine gets approved while public health workers deploy Janssen's
Source: Chemical and Engineering News - Category: Chemistry Authors: Source Type: research
Health authorities in eastern Congo have introduced a new Ebola vaccine produced by Johnson&Johnson, aid group MSF said on Thursday, to help combat the world's second-worst outbreak of the virus on record.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
[SAnews.gov.za] The National Institute for Communicable Diseases (NICD) says it has not had any positive Ebola cases in South Africa or its neighbouring countries.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
[News24Wire] Reports that a woman who displayed symptoms associated with the Ebola virus crossed the Ficksburg border in the Free State have been revealed to have been a simulation exercise.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
A new treatment for lung disease in cystic fibrosis (CF) for which there remains no cure could potentially benefit all patients, according to a University of Bristol study published in Chemical Science. The findings are an important step towards a new therapy addressing the fundamental cause of cystic fibrosis.
Source: University of Bristol news - Category: Universities & Medical Training Tags: Health, Research; Faculty of Life Sciences, Faculty of Life Sciences, School of Physiology, Pharmacology and Neuroscience, Faculty of Science, Faculty of Science, School of Chemistry; Press Release Source Type: news
Reena Goswami1, Gayatri Subramanian2, Liliya Silayeva1, Isabelle Newkirk1, Deborah Doctor1, Karan Chawla2, Saurabh Chattopadhyay2, Dhyan Chandra3, Nageswararao Chilukuri1 and Venkaiah Betapudi1,4* 1Neuroscience Branch, Research Division, United States Army Medical Research Institute of Chemical Defense, Aberdeen, MD, United States 2Department of Medical Microbiology and Immunology, University of Toledo College of Medicine and Life Sciences, Toledo, OH, United States 3Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States 4Department of Physiology and Biophysics, Case Western Reserve University, Clev...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
By ROMAN ZAMISHKA In the final act of Shakespeare’s Richard III, the eponymous villain king arrives on the battlefield to fight against Richmond, who will soon become Henry VII. During the battle, Richard is dismounted as his horse is killed and in a mad frenzy wades through the battlefield screaming “A horse, a horse! My kingdom for a horse!” Richard shows us how market value can change drastically depending on the circumstances, or your mental state, and even the most absurd exchange rate can become reasonable in a moment of crisis. This presumably arbitrary nature of prices should be the first t...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Economics Free Market health economics Libertarian Source Type: blogs
By ROMAN ZAMISHKA In the final act of Shakespeare’s Richard III the eponymous villain king arrives on the battlefield to fight against Richmond, who will soon become Henry VII. During the battle Richard is dismounted as his horse is killed and in a mad frenzy wades through the battlefield screaming “A horse, a horse! My kingdom for a horse!” Richard shows us how market value can change drastically depending on the circumstances, or your mental state, and even the most absurd exchange rate can become reasonable in a moment of crisis. This presumably arbitrary nature of prices should be the first thi...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Economics Source Type: blogs
In this study, researchers wanted to see why this is and if there could be any human applications.Researchers collected white blood cells from African and Asian elephants. They found that elephants have at least 20 copies of a gene called TP53. TP53 is known to encourage cell "suicide" when DNA is damaged, stopping any potential cancer in its tracks. In contrast, humans are thought to have only a single copy of the TP53 gene.Of course the big question – the elephant in the room, if you will – is how we can boost TP53 activity in humans to stimulate a similar protective effect. The simple answer is: we...
Source: NHS News Feed - Category: Consumer Health News Tags: QA articles Medical practice Special reports Source Type: news
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