Repeated Low-Grade Infections Predict Antidepressant-Resistant Depression: A Nationwide Population-Based Cohort Study.

CONCLUSIONS: This is the first large-scale retrospective cohort study to report a reliable temporal association between a history of RLGI and subsequent diagnosis of MDD and poor responses to antidepressants in 2 independent cohorts. Our data support the view that repeated mild infections play a role in the pathophysiology of MDD and antidepressant-resistant depression.
PMID: 29286591 [PubMed - as supplied by publisher]

Source: Journal of Clinical Psychiatry - December 30, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research