Hyperhomocysteinemia in acute iatrogenic hypothyroidism: the relevance of thyroid autoimmunity

AbstractPurposeHyperhomocysteinemia is a known cardiovascular risk factor and a key player in the inflammatory activation of autoimmune diseases. Hashimoto ’s thyroiditis (HT) is the leading cause of hypothyroidism which, in itself, has been associated with a significant raise of homocysteine (Hcy) levels and increased cardiovascular risk. Our aim was to assess the impact of HT on Hcy levels in patients with acute hypothyroidism.MethodsWe prospectively enrolled 121 patients (mean age: 46  years, F/M = 102/19) with acute post-surgical hypothyroidism. Based on the presence of anti-thyroid antibodies and the histological description of an inflammatory infiltrate, 26 and 95 patients were classified as HT and non-HT, respectively. Several parameters including thyroid-stimulating hormo ne (TSH), levels of serum free T3 and free T4, weight, glucose levels, total cholesterol, creatinine, vitamin B12, ferritin and erythrocyte sedimentation rate were obtained from all patients and correlated with Hcy levels.ResultsMedian Hcy level in the whole cohort was 16.8  µmol/L (normal values: 
Source: Journal of Endocrinological Investigation - Category: Endocrinology Source Type: research

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CONCLUSION: The genotypic distribution of Chr-11 tRNA-Lys-CUU in our population was consistent to that reported by others. This gene failed as a marker for T2DM predisposition. PMID: 30882233 [PubMed - as supplied by publisher]
Source: Future Medicine: Biomarkers in Medicine - Category: Internal Medicine Tags: Biomark Med Source Type: research
Research ArticlesA. P. Jones, K. Rueter, A. Siafarikas, E.-M. Lim, S. L. Prescott, D. J. Palmer,Journal of Developmental Origins of Health and Disease,Volume 7 Issue 04, pp 350-356Abstract
Source: Journal of Developmental Origins of Health and Disease - Category: Research Source Type: research
VITAMIN B12 is an essential vitamin for the body, but some people may struggle to get enough so choose to take supplements to get their levels topped up. But it ’s important to note one particular sign in your pee - it could mean you’ve had too much.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Abstract BACKGROUND AND PURPOSE: Although acute attacks of benign paroxysmal positional vertigo (BPPV) may be treated with canalith repositioning maneuvers, there have been no well-designed prospective trials to prevent this highly prevalent and recurrent disorder. This topical review explores the evidence related to the association between deficient calcium metabolism and BPPV. We also describe the development of therapeutic options to prevent recurrences of BPPV and introduce results from a recent randomized controlled trial on the effect of vitamin D and calcium supplementation in preventing BPPV recurrences. ...
Source: Physical Therapy - Category: Physiotherapy Authors: Tags: J Neurol Phys Ther Source Type: research
In conclusion, our work demonstrated that Rac1 inhibition alleviates collagen-induced arthritis through the decrease of platelet microparticles' release. In short, Rac1 aggravate the rheumatoid arthritis deterioration through the regulation of platelet microparticles formation. PMID: 30880553 [PubMed - as supplied by publisher]
Source: Platelets - Category: Hematology Tags: Platelets Source Type: research
Publication date: May 2019Source: Biomedicine &Pharmacotherapy, Volume 113Author(s): Mingzhu Ni, Binbin Zhang, Jianan Zhao, Qin Feng, Jinghua Peng, Yiyang Hu, Yu ZhaoAbstractNonalcoholic fatty liver disease (NAFLD) is becoming a worldwide health problem, but no approved medical treatment exists so far. Nuclear receptors are one of the drug targets for nonalcoholic steatohepatitis (NASH). Among them, liver X receptor (LXR) has been studied in recent years in tumors, metabolic diseases and inflammatory diseases, but its physiological and pharmacological effects in the treatment of NASH are controversial. Activation of LX...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
ConclusionsThe YL capsule was demonstrated to have obvious lipid regulatory effects, which are mainly exerted by targeting LXR and its related pathway. Lupeol and ginsenoside Rb3 were validated as Q-markers that represent the anti-hyperlipidemia activity of the capsule.Graphical Abstract
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research
The follow-up of celiac disease (CD) is challenging due to the scarcity of published data and the lack of standardized evidence-based protocols. The worldwide frequency and methods of CD follow-up appear to be heavily influenced by expert opinions of the individual physicians who assess children with CD. The aim of this review was to summarize the available studies on CD follow-up in children. We conducted a literature search with the use of PubMed, Medline, and Embase (from 1900 to 15 December 2016) for terms relevant to this review, including CD, follow-up, dietary adherence or dietary compliance, nutrition, comorbiditie...
Source: Advances in Nutrition - Category: Nutrition Authors: Tags: Reviews Source Type: research
This study aimed to determine the relationships between serum ADMA, endocan, TGF-β, and the high-sensitivity C-reactive protein (hs-CRP) levels, a proven indicator of ED, in patients with SH. METHODS: Thirty-five patients with SH and 21 age- and sex-matched euthyroid subjects were included in the study. The levels of TSH, FT4, lipid parameters, endocan, ADMA, TGF-β, and hs-CRP were measured. RESULTS: No significant differences in age or sex were found between the patient and control groups (p=0.294 and 0.881, respectively). Mean TSH level was higher in the patient group (p=0.005), whereas mean fT4 level...
Source: Annals of Clinical and Laboratory Science - Category: Laboratory Medicine Authors: Tags: Ann Clin Lab Sci Source Type: research
Rebecca shared her photos and experience living the Wheat Belly lifestyle: “Eliminating wheat has made such a huge difference in my health and, surprisingly, my appearance. I am 42 and have Hashimoto’s thyroiditis. I’m also a single mom of four and was told that it was ‘normal’ for me to be tired. But I was miserable. I was so tired it hurt despite having thyroid levels that were in the normal range. I also had brain ‘fog,’ anxiety, depression, and trouble sleeping. Doctor after doctor kept prescribing me more medicine: medicine for my mood, medicine to help me sleep. And despite a...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Wheat Belly Success Stories anti-aging anxiety Armour autoimmune Depression hashimoto's hypothyroid Inflammation insomnia leaky gut sleep Weight Loss youth Source Type: blogs
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