Silk Fibroin based Drug Delivery Applications: Promises and Challenges.

Silk Fibroin based Drug Delivery Applications: Promises and Challenges. Curr Drug Targets. 2017 Dec 27;: Authors: Din Wani SU, Veerabhadrappa GH Abstract BACKGROUND: Silk Fibroin (SF), a natural source material obtained from Bombyx mori, has been widely enlisted as biomaterial having outstanding mechanical properties. SF has been reported one of the propitious bio-polymer for various drug delivery systems, as well as drug delivery vehicle. OBJECTIVE: This review is summarised to provide in comprehensive applications of silk fibroin in various drug delivery systems, and also to present the current opportunities and requirements by furnishing a definitive assessment on silk fibroin as a polymer. RESULTS: SF has been reported one of the propitious bio-polymer for various drug delivery systems, as well as drug delivery vehicle. SF is inestimable owing to its non-toxic and non-antigenic character, except the firmness formation whilst stored at lower temperature. Unlike other polymeric biomaterials, SF regenerated in aqueous systems in defined temperature, pressure and pH, which is one of its major advantages in formulation. SF nanoparticles are also used to deliver proteins and peptides. Recently, SF is used to deliver anti-cancer agents like paclitaxel, doxorubicin, floxuridine, methotrexate, and including natural product curcumin shown to elicit significant biological activity when compared to their conventional form. Interestingly, SF is shown to...
Source: Current Drug Targets - Category: Drugs & Pharmacology Authors: Tags: Curr Drug Targets Source Type: research

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