Pathologic Perspectives on Acute Tubular Injury Assessment in the Kidney Biopsy

The molecular mechanisms in acute tubular injury (ATI) are complex and enigmatic. Moreover, we currently lack validated tissue injury markers that can be integrated into the kidney biopsy analysis to guide nephrologists in their patient ’s management of AKI. Although recognizing the ATI lesion by light microscopy is fairly straightforward, the staging of tubular lesions in the context of clinical time course and etiologic mechanism currently is not adapted to the renal pathology practice. To the clinician, the exact time point wh en an ischemic or toxic injury has occurred often is not known and cannot be discerned from the review of the biopsy sample.
Source: Seminars in Nephrology - Category: Urology & Nephrology Authors: Source Type: research