Zoledronic acid increases the prevalence of medication-related osteonecrosis of the jaw in a dose dependent manner in rice rats (Oryzomys palustris) with localized periodontitis

Investigate role of dose/duration of zoledronic acid (ZOL), a powerful anti-resorptive (pAR), on prevalence of medication-related osteonecrosis of the jaw (MRONJ) in rice rats (Oryzomys palustris), a species with natural susceptibility to food impaction-induced localized periodontitis (FILP). We hypothesize that ZOL induces MRONJ lesions in rice rats with FILP, and that the prevalence of MRONJ rises with increasing dose and duration of ZOL treatment.

Source: Bone - December 28, 2017 Category: Orthopaedics Authors: J.G. Messer, J.L. Mendieta Calle, J.M. Jiron, E.J. Castillo, C. Van Poznak, N. Bhattacharyya, D.B. Kimmel, J.I. Aguirre Tags: Full Length Article Source Type: research