Correction to Global Awakening of Cryptic Biosynthetic Gene Clusters in Burkholderia thailandensis

ACS Chemical BiologyDOI: 10.1021/acschembio.7b01056
Source: ACS Chemical Biology - Category: Chemistry Authors: Source Type: research

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DNA vaccines have great potential to control infectious disease, particularly those caused by intracellular organisms. They are inexpensive to produce and can be quickly modified to combat emerging infectious threats, but often fail to generate a strong immunologic response limiting enthusiasm for their use in humans and animals. To improve the immunogenic response, we developed a DNA vaccine in which the F protein ectodomain of Respiratory Syncytial Virus (RSV-F) was covalently linked to specific antigens of interest. The presence of the RSV-F ectodomain allowed secretion of the translated fusion product out of the origin...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Publication date: Available online 8 October 2019Source: Soil Biology and BiochemistryAuthor(s): Daniel C. Schlatter, Christopher M. Baugher, Kahl Kendall, David R. Huggins, Jodi L. Johnson-Maynard, Timothy C. PaulitzAbstractEarthworms are important ecosystem engineers and modify the physical and chemical properties of soils. However, less is known about how earthworms impact soil microbial communities. We compared bacterial communities of the bulk soil and earthworm casts in native prairie remnants and wheat cropped fields in the Palouse of Eastern Washington using next-generation sequencing. Communities among prairie sit...
Source: Soil Biology and Biochemistry - Category: Biology Source Type: research
Microbial Drug Resistance, Ahead of Print.
Source: Microbial Drug Resistance - Category: Microbiology Authors: Source Type: research
CONCLUSION: Young boys were found to be more commonly affected by orbital cellulitis than young girls. Staphylococcus aureus was the most common isolated micro-organism. Methicillin-resistant Staphylococcus aureus and Burkholderia pseudomallei caused severe infection. Sinusitis and upper respiratory tract infection were the most common predisposing factors. A majority of the children improved with medical treatment alone. Our findings are in slight disagreement with other published reports on paediatric orbital cellulitis, especially from the Asian region. PMID: 31598730 [PubMed - as supplied by publisher]
Source: Singapore Medical Journal - Category: General Medicine Authors: Tags: Singapore Med J Source Type: research
Publication date: Available online 3 October 2019Source: Biological ControlAuthor(s): Hoki Kim, Tapan Kumar Mohanta, Young-Hwan Park, Soo-Chul Park, Gnanendra Shanmugam, Jin-Soo Park, Junhyun Jeon, Hanhong BaeAbstractGinseng (Panax ginseng Meyer) is one of the most important perennial medicinal plants. Ginseng is vulnerable to life-threatening diseases like root rot, blight, damping off, and spotting diseases because of its long cultivation period. Chemical control has numerous drawbacks for the plant and environment. Therefore, there is an immediate demand to replace the chemical agents with biological agents. We isolated...
Source: Biological Control - Category: Biology Source Type: research
This study enriches the inhibitory profiles database for γ-class CAs and promotes the identification of new potent and selective inhibitors against bacterial isoforms over human off-target ones. These agents are of remarkable interest and importance in the search of novel, worldwide required, antibiotic agents possessing alternative mechanisms of action as a strategy to overcome the spread to antimicrobic resistance. PMID: 31604186 [PubMed - as supplied by publisher]
Source: Bioorganic Chemistry - Category: Chemistry Authors: Tags: Bioorg Chem Source Type: research
In this study, the PHA synthase gene of B. contaminans Kad1 (phaCBcon) was successfully cloned and characterized. Heterologous expression of phaCBcon conferred PHA synthesis to the mutant Cupriavidus necator PHB¯4, confirming that phaCBcon encoded a functional active protein. The transformant C. necator PHB¯4 (Cn-Kad1) harboring phaCBcon was able to synthesize PHA when grown on sodium-4-hydroxybutyrate (sodium-4-HB) as the sole carbon source in a two-stage cultivation. NMR results confirmed the presence of poly(3-hydroxybutyrate-co-4-hydroxybutyrate), P(3HB-co-4HB). Cn-Kad1 has the ability to produce a broad rang...
Source: Biochemical Engineering Journal - Category: Biochemistry Source Type: research
We identified two poplar (Populus sp.)-associated microbes, the fungus, Mortierella elongata strain AG77, and the bacterium, Burkholderia strain BT03, that mutually promote each other’s growth. Using culture assays in concert with a novel microfluidic device to generate time-lapse videos, we found growth specific media differing in pH and pre-conditioned by microbial growth led to increased fungal and bacterial growth rates. Coupling microfluidics and comparative metabolomics data results indicated that observed microbial growth stimulation involves metabolic exchange during two ordered events. The first is an emissi...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Publication date: Available online 30 September 2019Source: Journal of Hazardous MaterialsAuthor(s): Jiayu Zhang, Renxin Zhao, Lijia Cao, Yusha Lei, Jie Liu, Jie Feng, Wenjie Fu, Xiaoyan Li, Bing LiAbstractThe risk of environmental pollution caused by chloramphenicol has necessitated special attention. Biodegradation has tremendous potential for chloramphenicol removal in the environment. Six chloramphenicol-degrading consortia were acclimated under different culture conditions to investigate their chloramphenicol biodegradation behaviors, and the bacterial community structures were comprehensively characterized. The enric...
Source: Journal of Hazardous Materials - Category: Environmental Health Source Type: research
Molecules, Vol. 24, Pages 3550: A Selective, Dual Emission β-Alanine Aminopeptidase Activated Fluorescent Probe for the Detection of Pseudomonas aeruginosa, Burkholderia cepacia, and Serratia marcescens Molecules doi: 10.3390/molecules24193550 Authors: Linda Váradi Elias Y. Najib David E. Hibbs John D. Perry Paul W. Groundwater Selective detection of β-alanyl aminopeptidase (BAP)-producing Pseudomonas aeruginosa, Serratia marcescens, and Burkholderia cepacia was achieved by employing the blue-to-yellow fluorescent transition of a BAP-specific enzyme substrate, 3-hydroxy-2-(p-dimethylami...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
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