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Study: Legacy pacers, ICDs found safe for 1.5T MRI scans

Pacemakers and implantable cardioverter defibrillators not marked as MRI-safe could still be mostly safe to use during imaging sessions with 1.5T MRI machines, according to a new study reported on by Healio. Results from the study were recently published in The New England Journal of Medicine. In the prospective, nonrandomized study, researchers aimed to explore the safety of 1.5T MRI sessions in 1,509 patients with legacy pacemakers or ICDs, undergoing a total of 2,103 MRI exams. Pacing mode in the devices was changed to asynchronies in pacing dependent patients and demand mode for other patients, with tachyarrhythmia functions disabled, according to Healio. No clinically significant adverse events were reported at 1 year, according to the report, and only 0.4% of the devices reset to backup mode during MRI exams. A single pacer with a month of battery life was noted as having reset to ventricular inhibited pacing, could not be reprogrammed and was replaced, according to the report. A decrease P-wave amplitude of at least 50% from baseline also occurred in 1% of patients, according to Healio. On a longer term follow-up, 4% of patients had reported decreases in P-wave amplitude, with 4% experiencing an increase in atrial capture threshold, 4% exhibiting an increase in right ventricular capture threshold and 3% showing an increase in left ventricular capture threshold, according to the report. None of these results were clinically significant or required device reprogramming o...
Source: Mass Device - Category: Medical Devices Authors: Tags: Cardiac Assist Devices Cardiac Implants Cardiovascular Clinical Trials Imaging Source Type: news

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Publication date: 21 February 2018 Source:The Lancet, Volume 391, Supplement 2 Author(s): Amir Abukaresh, Rami Al-Abadlah, Bettina Böttcher, Khamis El-Essi Background In the 2014 Palestinian annual health report, cerebrovascular accident was ranked as the third leading cause of death in the occupied Palestinian territory. Cerebrovascular accident is also one the most common causes of disability worldwide. Good management decreases mortality and morbidity. The aim of this study was to assess the current management of patients with ischaemic stroke at the Al-Shifa Hospital and to compare this with international guideli...
Source: The Lancet - Category: General Medicine Source Type: research
CONCLUSIONS: Given that other second-line therapies have demonstrated efficacy in RA patients who failed to respond to TNF-α inhibitors, these findings may suggest that interleukin-17A inhibition with secukinumab does not provide additional benefit to these patients. This study further confirms the well-characterized safety profile of secukinumab. PMID: 29458278 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Rheumatology - Category: Rheumatology Authors: Tags: Scand J Rheumatol Source Type: research
This study explored the influence of certain personality traits (neuroticism, extraversion, psychoticism, alexithymia), emotional variables (depression, catastrophizing), and insomnia on cerebral blood flow (CBF) responses to painful stimulation in fibromyalgia, using functional transcranial Doppler sonography. CBF velocities were recorded bilaterally in the anterior cerebral arteries (ACA) and middle cerebral arteries (MCA) of 24 fibromyalgia patients during exposure to two painful pressure conditions: (1) fixed pressure (2.4 kg) and (2) an individually calibrated pressure to produce an equal‐moderate subjective pain in...
Source: Scandinavian Journal of Psychology - Category: Psychiatry & Psychology Authors: Tags: Health and Disability Source Type: research
Abstract Skin injuries represent a health problem with consequences in terms of morbidity, disability and life quality. Numerous strategies have been developed for the treatment of wounds, including skin substitutes, biomembranes, scaffolds, and smart dressings. The excellent properties of fibroin can be exploited for the development of advanced wound dressing biomaterials, aiming at promoting the wound healing process. In this work, silk fibroin films modified through the addition of glucose were developed to enhance flexibility of medical device without affecting the biocompatibility, to promote wound healing and to impr...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - Category: Materials Science Authors: Tags: Original Research Report Source Type: research
JoAnn Wooding is staring intently at the clear liquid dripping from a dark brown IV bag into her husband Peter’s arm. “Please be the drug, please be the drug,” she says. Married for more than 50 years, the Woodings are among the more than 5 million Americans who are facing Alzheimer’s disease, one of the most devastating diagnoses today. But instead of accepting the slow descent into memory loss, confusion and dementia, Peter–who has the disease–could be among the first to successfully stop that decline from happening. Peter, 77, is one of the 2,700 people around the world who are expect...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Alzheimer's Disease healthytime Longevity Source Type: news
Abstract OBJECTIVE: The goal of this analysis was to provide a contemporary estimate of the burden of migraine, incorporating both direct and indirect costs, by comparing the costs of migraine patients to a matched group of patients without migraine in a large, nationally representative sample of commercially insured patients in the United States. BACKGROUND: Previous studies have shown that the economic burden of migraine in the United States is substantial for payers, patients, and employers. Despite the availability of multiple acute and preventive pharmacological treatment options and a relatively stable ...
Source: Headache - Category: Neurology Authors: Tags: Headache Source Type: research
ObjectiveThe goal of this analysis was to provide a contemporary estimate of the burden of migraine, incorporating both direct and indirect costs, by comparing the costs of migraine patients to a matched group of patients without migraine in a large, nationally representative sample of commercially insured patients in the United States. BackgroundPrevious studies have shown that the economic burden of migraine in the United States is substantial for payers, patients, and employers. Despite the availability of multiple acute and preventive pharmacological treatment options and a relatively stable migraine prevalence in the ...
Source: Headache: The Journal of Head and Face Pain - Category: Neurology Authors: Tags: Research Submissions Source Type: research
Abstract BackgroundChronification of pain is associated with both anatomical and functional alterations of the brain. Alteration in regional gray matter volume might potentially be associated with modified activity of specific brain networks. In this cross‐sectional, observational study, we sought to identify brain regions with gray matter volume changes in patients with chronic pain and to reveal its significance by analysing alteration in functional connectivity from those regions. We further explored relevance of such alterations with psychometrics of chronic pain. MethodsWe recruited 23 patients with chronic pain and...
Source: European Journal of Pain - Category: Anesthesiology Authors: Tags: Original Article Source Type: research
AbstractAim of the studyThe aim of this study was to evaluate union rate and clinical outcome in patients with proximal humeral nonunions treated by open reduction and locking plate fixation without bone grafting.MethodsFrom 2011 to 2016, nine patients were treated using open reduction and locking plate stabilization without bone grafting. They were examined both clinically and radiologically, with a mean follow-up period of 31  months. Outcome was evaluated using pain and range of motion (ROM) parameters. In addition, self-assessment by patients was registered on the Disability of the Arm, Shoulder and Hand score, Co...
Source: International Orthopaedics - Category: Orthopaedics Source Type: research
In conclusion, direct injection of lactacystin into the MFB of minipigs provides a model of PD with reduced dopamine neurotransmission, TH-positive neuron reduction, microglial activation and behavioural deficits. This large animal model could be useful in studies of symptomatic and neuroprotective therapies with translatability to human PD. PMID: 29428213 [PubMed - as supplied by publisher]
Source: Experimental Neurology - Category: Neurology Authors: Tags: Exp Neurol Source Type: research
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