Study: Legacy pacers, ICDs found safe for 1.5T MRI scans

Pacemakers and implantable cardioverter defibrillators not marked as MRI-safe could still be mostly safe to use during imaging sessions with 1.5T MRI machines, according to a new study reported on by Healio. Results from the study were recently published in The New England Journal of Medicine. In the prospective, nonrandomized study, researchers aimed to explore the safety of 1.5T MRI sessions in 1,509 patients with legacy pacemakers or ICDs, undergoing a total of 2,103 MRI exams. Pacing mode in the devices was changed to asynchronies in pacing dependent patients and demand mode for other patients, with tachyarrhythmia functions disabled, according to Healio. No clinically significant adverse events were reported at 1 year, according to the report, and only 0.4% of the devices reset to backup mode during MRI exams. A single pacer with a month of battery life was noted as having reset to ventricular inhibited pacing, could not be reprogrammed and was replaced, according to the report. A decrease P-wave amplitude of at least 50% from baseline also occurred in 1% of patients, according to Healio. On a longer term follow-up, 4% of patients had reported decreases in P-wave amplitude, with 4% experiencing an increase in atrial capture threshold, 4% exhibiting an increase in right ventricular capture threshold and 3% showing an increase in left ventricular capture threshold, according to the report. None of these results were clinically significant or required device reprogramming o...
Source: Mass Device - Category: Medical Devices Authors: Tags: Cardiac Assist Devices Cardiac Implants Cardiovascular Clinical Trials Imaging Source Type: news

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AbstractImpaired nerve conduction, axonal degeneration, and synaptic alterations contribute to neurological disabilities in inflammatory demyelinating diseases. Cerebellar dysfunction is associated with demyelinating disorders, but the alterations of axon terminals in cerebellar gray matter during chronic demyelination are still unclear. We analyzed the morphological and ultrastructural changes of climbing fiber terminals in a mouse model of hereditary chronic demyelination. Three-dimensional ultrastructural analyses using serial block-face scanning electron microscopy and immunostaining for synaptic markers were performed...
Source: Medical Molecular Morphology - Category: Molecular Biology Source Type: research
By SAURABH JHA Of my time arguing with doctors, 30 % is spent convincing British doctors that their American counterparts aren’t idiots, 30 % convincing American doctors that British doctors aren’t idiots, and 40 % convincing both that I’m not an idiot. A British doctor once earnestly asked whether American physicians carry credit card reading machines inside their white coats. Myths about the NHS can be equally comical. British doctors don’t prostate every morning in deference to the NHS, like the citizens of Oceania sang to Big Brother in Orwell’s dystopia. Nor, in their daily rounds, do the...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: OP-ED Uncategorized AlfieEvans Source Type: blogs
Conclusion Implications for programs and policy include developing and adopting rigorous ways to measure and carefully monitor service provision, including assessments of paternal competence, family relationships and informal supports at the start of early intervention, and fostering continuous collaborations between providers, researchers and clinicians to address challenges in data collection.
Source: Research in Developmental Disabilities - Category: Disability Source Type: research
The GMR office is excited to announce that Wisconsin Health Literacy (WHL) has been granted a Health Information Outreach Award for its project, Health Online: Finding Information You Can Trust. Background: A recent WHL survey of literacy tutors found that a significant number of their adult students wish they could do better in finding online information on health symptoms, resources to help them stay healthy, and resources in other languages. Nearly half also wanted help scanning health websites to find what’s relevant to them. These needs may result in part from the fact that those with low literacy use websites ...
Source: The Cornflower - Category: Databases & Libraries Authors: Tags: Funding Source Type: news
Conclusions: Our study demonstrates that the DCE-MRI with the extended Tofts linear model can measure the permeability and perfusion characteristic in MS lesions and in NAWM regions. The Ktrans, Ve, Vp, CBF, and CBV of CE lesions were significantly higher than that of NE lesions. The skewness of Ve value in CE lesions was more close to normal distribution, indicating that the histogram can be helpful to distinguish the pathology of MS lesions.
Source: Neurology India - Category: Neurology Authors: Source Type: research
AbstractUnraveling the causes and pathomechanisms of progressive disorders is essential for the development of therapeutic strategies. Here, we identified heterozygous pathogenic missense variants ofLMX1A in two families of Dutch origin with progressive nonsyndromic hearing impairment (HI), using whole exome sequencing. One variant, c.721G  >  C (p.Val241Leu), occurred de novo and is predicted to affect the homeodomain of LMX1A, which is essential for DNA binding. The second variant, c.290G >  C (p.Cys97Ser), predicted to affect a zinc-binding residue of the second LIM domain that is invol...
Source: Human Genetics - Category: Genetics & Stem Cells Source Type: research
There has been considerable and well-deserved publicity regarding cases where implicit or explicit police bias has led to unwarranted arrests and shooting of unarmed black individuals. The Starbucks case illustrates how a black man waiting at a place of business can be construed as loitering or engaging in disorderly conduct. A black man standing in his backyard with a telephone in his hand can be shot as a potentially dangerous suspect. About 22-25% of people shot and killed by police in 2017 were unarmed black men (Sullivan, Anthony, Tate, &Jenkins, 2018). How many of these shootings were necessary? It is similarly t...
Source: Psych Central - Category: Psychiatry Authors: Tags: Bipolar Personal Stories Policy and Advocacy Psychological Assessment Psychology Treatment Bias Bipolar Disorder Hospitalization Prejudice race Source Type: news
Conclusion This study showed adherence to many of the assessments and interventions suggested in the Care Considerations. The areas showing less consistency could be classified as derived from expert opinion with little supporting data. Improvement in the implementation of all aspects of recommended care requires continued study into the health impact of the proposed recommendations and continued advocacy for coverage by agencies. Corresponding Author Kristin Conway, PhD, Department of Epidemiology, College of Public Health, The University of Iowa, Iowa City, Iowa 52240, USA; Telephone: 319-335-4641 Email: kristin-casper...
Source: PLOS Currents Muscular Dystrophy - Category: Neurology Authors: Source Type: research
AbstractPurpose of ReviewFrailty is associated with serious adverse outcomes, such as disability, health care utilization, and death in the perioperative period. In this review, we discuss surgical outcomes in a frail individual, and risk stratification for a frail individual.Recent FindingsFrailty is associated with increased length of hospital stay and 30- and 90-day mortality. The data on association of frailty on discharge to home and quality of life is scant, but it is likely that they are closely related. Prehabilitation involving a diet and exercise program seems to improve outcomes in the frail surgical candidates....
Source: Current Anesthesiology Reports - Category: Anesthesiology Source Type: research
ConclusionThe study showed that the extreme lateral approach to the lumbar spine in case of isthmic spondylolisthesis is a reliable and safe option to the most common open procedures. In the authors ’ opinion, XLIF procedures allow a good correction of the listhesis associated with good clinical and radiographic results.Graphical abstractThese slides can be retrieved under Electronic supplementary material.
Source: European Spine Journal - Category: Orthopaedics Source Type: research
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