Frailty Syndrome: A Problem in the Management of Arrhythmias Frailty Syndrome: A Problem in the Management of Arrhythmias

How prevalent is frailty in everyday practice and how does it influence the clinical management of arrhythmias?Europace
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Cardiology Journal Article Source Type: news

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Use of a NobleStitch™ EL Device for PFO Closure. Surg Technol Int. 2018 Jun 01;32:219-223 Authors: de Cillis E, Acquaviva T, D'Alessandro P, Bortone AS Abstract Cryptogenic stroke is the final diagnosis in almost 40% of ischemic acute cerebrovascular events. There is currently no definitive clinical evidence that percutaneous closure of patent foramen ovale (PFO) can prevent the recurrence of stroke or transient ischemic attack (TIA). Identification of the causes of neurologic ischemic syndromes is essential for any strategy intended to prevent the catastrophic consequences of cerebral infarction. Sin...
Source: Surgical Technology International - Category: Surgery Tags: Surg Technol Int Source Type: research
AbstractBackgroundFinding the conduction gaps in redo PV isolation procedures is challenging, and several maneuvers have been described. In the present study, we analyze the pace and map (P&M) maneuver [atrial mapping during pulmonary vein (PV) pacing] to locate the gaps in redo PV isolation procedures.MethodsConsecutive patients undergoing a second PV isolation procedure at a single institution over a 4-year period were included. For the last 2  years, all the patients (n = 38) studied underwent PV isolation based on the P&M maneuver and were compared to the previous patients (n = 45). The...
Source: Journal of Interventional Cardiac Electrophysiology - Category: Cardiology Source Type: research
AbstractPurpose of ReviewCardiovascular disease is the leading contributor to mortality and morbidity. Many deaths of heart failure patients can be attributed to sudden cardiac death due primarily to ventricular arrhythmia. Currently, most anti-arrhythmics modulate ion channel conductivity or β-adrenergic signaling, but these drugs have limited efficacy for some indications, and can potentially be proarrhythmic.Recent FindingsRecent studies have shown that mutations in proteins other than cardiac ion channels may confer susceptibility to congenital as well as acquired arrhythmias. Additionally, ion channels themselves...
Source: Current Cardiology Reports - Category: Cardiology Source Type: research
Publication date: August 2018 Source:Biomedicine & Pharmacotherapy, Volume 104 Author(s): Elaheh Mirhadi, Mehdi Rezaee, Bizhan Malaekeh-Nikouei Berberine, as a phytochemical component of some medicinal Chinese herbs (most frequently Berberis vulgaris), is an isoquinoline alkaloid with many therapeutic effects including anti-viral, anti-microbial, anti-diarrhea, anti-inflammatory and anti-tumor effects. Berberine has some significant effects on type 2 diabetes through adenosine monophosphate-activated protein kinase activation, glycolysis stimulation, and mitochondrial function inhibition which subsequently improves bo...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Conclusions In patients with recurrent unexplained palpitations, evaluation by means of a study protocol that considers the systematic use of a latest-generation ELR increases diagnostic yield while reducing the cost per diagnosis.
Source: Revista Espanola de Cardiologia - Category: Cardiology Source Type: research
3 out of 5 stars Severe loperamide toxicity associated with the use of cimetidine to potentiate the “high.” Hughes A et al. AM J Emerg Med 2018 May 15 [Epub ahead of print] Reference The potential adverse effects of loperamide (Imodium) are often underestimated since, even though it is an opioid, it is available over-the-counter and has been since 1988. Loperamide is used to treat diarrhea. It acts on the mu-opioid receptors in the gut, decreasing gastric motility. It is rather effective at this. However at therapeutic doses (2-16 mg per day) it does not cause central opioid effects such as euphoria or rel...
Source: The Poison Review - Category: Toxicology Authors: Tags: Medical imodium loperamide overdose toxicity Source Type: news
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog Eponyms can be confusing and open to misinterpretation. By plotting the historical course of their folksonomic semantic derivation we gain a deeper understanding of the condition, the authors and the eponym. We review the early development of arrhythmia recording and the contributions of Luciani, Galabin, Gaskell, Wenckebachh, Hay and Mobitz to the current terminology associated with the categorization of Second-degree Atrioventricular block Current terminology Mob...
Source: Life in the Fast Lane - Category: Emergency Medicine Authors: Tags: Eponymythology Atrioventricular block AV block Galabin Gaskell Hay Hay AV Block Luciani Mobitz Second-degree wenckebach Wenckebach AV Block Source Type: blogs
by Caroline H. Roney, Jason D. Bayer, Hubert Cochet, Marianna Meo, R émi Dubois, Pierre Jaïs, Edward J. Vigmond Success rates for catheter ablation of persistent atrial fibrillation patients are currently low; however, there is a subset of patients for whom electrical isolation of the pulmonary veins alone is a successful treatment strategy. It is difficult to identify these patients because there are a mul titude of factors affecting arrhythmia susceptibility and maintenance, and the individual contributions of these factors are difficult to determine clinically. We hypothesised that the combination of pulmon...
Source: PLoS Computational Biology - Category: Biology Authors: Source Type: research
This article reviews relevant definitions, epidemiology, pathophysiology, diagnosis, and clinical management.
Source: Otolaryngologic clinics of North America - Category: ENT & OMF Authors: Source Type: research
The objective of this 16-week, double-blind, single-center thorough QT study was to confirm that semaglutide treatment does not prolong cardiac repolarization versus placebo. Prolongation of the QT interval is a biomarker for ventricular tachyarrhythmia.MethodsIn a parallel design, 168 healthy subjects were randomized to the treatment or placebo arms, of whom 166 were treated with subcutaneous semaglutide (N = 83; escalated to a supratherapeutic dose of 1.5 mg) or placebo (N = 83). The subjects (60% males) had a mean age of 38.2 years and body mass index of 25.1 kg/m2. To assess QT assay sensitivity, subjects in the placeb...
Source: Diabetes Therapy - Category: Endocrinology Source Type: research
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