The sisters with childhood Alzheimer's

Both Abby, three, and Belle, seven, have Niemann-Pick Type C1, a genetic disease where in time, children slowly regress until they can ’t walk, eat, and dementia will set in before age 10.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Confronting the stigma and isolation people with dementia face in some communities around the world.
Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news
Confronting the stigma and isolation people with dementia face in some communities around the world.
Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news
Evidence suggests a link between residential levels of air pollution across London and being diagnosed with dementia, according to researchers.
Source: Nursing Times - Category: Nursing Source Type: news
It seems shocking to hear people ask whether dementia, particularly Alzheimer’s since it’s the best known, is as hard on the caregiver as it is on the person with the disease. After all, developing dementia of any kind is one of our greatest fears, even overtaking cancer. A caregiver who asks this question must be incredibly heartless and selfish, right? Yet, people who've never been a caregiver for someone with dementia need to think this through. When a loved one develops dementia, both the care receiver and the caregiver have entered an incredibly challenging time in their lives. Read the full article on Hea...
Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
(MedPage Today) -- Nearly 14 million Americans may have Alzheimer's disease by then
Source: MedPage Today Psychiatry - Category: Psychiatry Source Type: news
Niemann-Pick disease type C (NP-C) is a rare, progressive neurodegenerative disease caused by mutations in the NPC1 or the NPC2 gene. Neurocognitive deficits are common in NP-C, particularly in patients with the ...
Source: Orphanet Journal of Rare Diseases - Category: Internal Medicine Authors: Tags: Research Source Type: research
Both Abby, three, and Belle, seven, have Niemann-Pick Type C1, a genetic disease where in time, children slowly regress until they can ’t walk, eat, and dementia will set in before age 10.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Hydroxypropyl-β-cyclodextrin formulated in nasal chitosan microspheres as candidate therapeutic agent in Alzheimer's disease. Curr Drug Deliv. 2017 Oct 19;: Authors: Rassu G, Gavini E, Carta A, Obinu A, Porcu EP, Giunchedi P Abstract Hydroxypropyl-β-cyclodextrin (HP-CD) is a hydroxyalkyl derivative of native β-cyclodextrin, cyclic oligosaccharide able to form inclusion complexes with many drugs and biomolecules [1]. Cyclodextrins have a possible neuroprotective effect due to their capability to extract and deplete cholesterol from cell membranes [1]. HP-CD is classified as an excipient ...
Source: Current Drug Delivery - Category: Drugs & Pharmacology Authors: Tags: Curr Drug Deliv Source Type: research
Conclusions: Diagnosis of ANCL remains challenging; expert pathologic analysis and recent molecular genetic advances revealed misdiagnoses in>1/3 of cases. We now have a refined group of cases that will facilitate identification of new causative genes.
Source: Neurology - Category: Neurology Authors: Tags: All Movement Disorders, All Cognitive Disorders/Dementia ARTICLE Source Type: research
Abstract Trisomy 21 and the consequent extra copy of the amyloid precursor protein (APP) gene and increased beta-amyloid (Aβ) peptide production underlie the universal development of Alzheimer's disease (AD) pathology and high risk of AD dementia in people with Down syndrome (DS). Trisomy 21 and other forms of aneuploidy also arise among neurons and peripheral cells in both sporadic and familial AD and in mouse and cell models thereof, reinforcing the conclusion that AD and DS are two sides of the same coin. The demonstration that 90% of the neurodegeneration in AD can be attributed to the selective loss of a...
Source: Current Alzheimer Research - Category: Neurology Authors: Tags: Curr Alzheimer Res Source Type: research
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