Many layers of embryonic hematopoiesis: new insights into B cell ontogeny and the origin of hematopoietic stem cells

• During embryonic development, initial hematopoietic progenitors are generated from hemogenic endothelium in multiple waves independently of HSC.• Recent studies highlight the contribution of embryonic waves of HSC-independent hematopoiesis to unique innate-like immune cells that can persist as self-maintaining hematopoietic populations in adult tissues.• Recent studies suggest that distinct waves of hemogenic endothelium/HSC precursors may contribute to the production of heterogeneous populations of HSC in the fetal liver with distinct self-renewal properties and B cell lineage potenti als.
Source: Experimental Hematology - Category: Hematology Authors: Source Type: research