A prospective cohort and extended comprehensive-cohort design provided insights about the generalizability of a pragmatic trial: the ProtecT prostate cancer trial
Randomized controlled trials (RCTs) deliver robust internally valid evidence but generalizability is often neglected. Design features built into the ProtecT RCT of treatments for localized prostate cancer (PCa) provided insights into its generalizability.
Source: Journal of Clinical Epidemiology - Category: Epidemiology Authors: Jenny L. Donovan, Grace J. Young, Eleanor I. Walsh, Chris Metcalfe, J. Athene Lane, Richard M. Martin, Marta K. Tazewell, Michael Davis, Tim. J. Peters, Emma L. Turner, Nicola Mills, Hanan Khazragui, Tarnjit K. Khera, David E. Neal, Freddie C. Hamdy, Prot Source Type: research