Mapranosis: the Influence of Commensal Microbes on Neurodegenerative Disease

Commensal microbes are the largely helpful populations that live inside us, usually meaning the gut microbiota, but there are others, such as the bacteria found in the mouth. Among these largely helpful microbes are a range of species that cause us harm over the years, however - consider the bacterial origins of gum disease, for example. Researchers are increasingly interested in the ways in which the swarming microbial life inside us, and particularly in the gut, might influence the progression of aging; to what degree are gut bacteria a cause of the observed natural variations in pace and outcome of aging in mammals? This is an open question. In the case of neurodegenerative conditions such as Alzheimer's disease, microbial life may contribute by generating some fraction of the amyloid deposits or chronic inflammation known to be associated with the condition. In this context, some scientists are focused on invading microbes such as spirochetes, while others, like those noted here, are more interested in the commensal microbes that normally live inside us. There is a fair amount of evidence for either of these two classes of microbe to be involved. Research in the past two decades has revealed that microbial organisms in the gut influence health and disease in many ways, particularly related to immune function, metabolism, and resistance to infection. Recent studies have shown that gut microbes also may cause or worsen Parkinson's disease, Alzheimer's diseas...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs

Related Links:

Fatima Concei ção-Silva, Jessica Leite-Silva, Fernanda N. Morgado
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Conclusion: Ultrasound imaging and ambulatory blood pressure measurements enhanced with physiological modeling can improve MCI diagnosis accuracy.
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research
Anti-malarial pre-erythrocytic vaccines (PEV) target transmission by inhibiting human infection but are currently partially protective. It has been posited, but never demonstrated, that co-administering transmission-blocking vaccines (TBV) would enhance malaria control. We hypothesized a mechanism that TBV could reduce parasite density in the mosquito salivary glands, thereby enhancing PEV efficacy. This was tested using a multigenerational population assay, passagingPlasmodium berghei toAnopheles stephensi mosquitoes. A combined efficacy of 90.8% (86.7 –94.2%) was observed in the PEV +TBV antibody group, higher than...
Source: eLife - Category: Biomedical Science Tags: Epidemiology and Global Health Microbiology and Infectious Disease Source Type: research
AbstractSpinocerebellar ataxia type 8 (SCA8) is a rare autosomal dominant neurodegenerative disease caused by expanded CTA/CTG repeats in theATXN8OS gene. Many patients had pure cerebellar ataxia, while some had parkinsonism, both without causal explanation. We analyzed theATXN8OS gene in 150 Japanese patients with ataxia and 76 patients with Parkinson ’s disease or related disorders. We systematically reassessed 123 patients with SCA8, both our patients and those reported in other studies. Two patients with progressive supranuclear palsy (PSP) had mutations in theATXN8OS gene. Systematic analyses revealed that patie...
Source: The Cerebellum - Category: Neurology Source Type: research
The parallel placebo-controlled study examined the therapeutic effects of dual-target repetitive transcranial magnetic stimulation (rTMS) of the motor cortex (bilaterally) and the left prefrontal cortex (dorsolaterally) on spontaneous and mitogen-stimulating synthesis of pro- and anti-inflammatory cytokines by the blood cells and the level of brain-derived neurotrophic factor (BDNF) in blood serum of patients with Parkinson ’s disease. The significantly steeper positive clinical dynamics (assessed by UPRSD scale) observed in rTMS group in comparison with the placebo group was accompanied by a significant drop in spon...
Source: Bulletin of Experimental Biology and Medicine - Category: Biology Source Type: research
In conclusion, we have identified an analog of curcumin for potential applications against leishmaniasis, based on its strong antiparasitic activity and low toxicity. This curcumin analog compares favorably, at least in vitro, with the existing medication miltefosine. Graphical abstract
Source: Parasitology International - Category: Parasitology Source Type: research
In conclusion, our results suggest that line differences in productive performance do not influence host responses to coccidiosis when offered nutrient adequate diets. Graphical abstract
Source: Veterinary Parasitology - Category: Veterinary Research Source Type: research
Publication date: Available online 18 June 2018 Source:Ticks and Tick-borne Diseases Author(s): Ana Paula S. Feitosa, Marlos M. Chaves, Dyana L. Veras, Dayse M. Vasconcelos de Deus, Nairomberg C. Portela, Alberon R. Araújo, Luiz C. Alves, Fábio A. Brayner The aim of this study was to evaluate aspects of the innate cellular and humoral immune response by evaluating hemocyte dynamics, phagocytosis, phenoloxidase (PO) activity and nitric oxide (NO) production in Rhipicephalus sanguineus sensu lato (s.l.) (Acari: Ixodidae) infected with Leishmania infantum and to assess the persistence of parasites at time 0 and...
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
This study shows for the first time that increasing arterial stiffness is detrimental to the brain, and that increasing stiffness and brain injury begin in early middle life, before we commonly think of prevalent diseases such as atherosclerosis, coronary artery disease or stroke having an impact." The study also noted that elevated arterial stiffness is the earliest manifestation of systolic hypertension. The large study involved approximately 1,900 diverse participants in the Framingham Heart Study, who underwent brain magnetic resonance imaging (MRI), as well as arterial tonometry. The tests measured the force o...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
This article covers the lengthy process of turning a serendipitous discovery, that a particular phage can dissolve the amyloids and other aggregates involved in neurodegenerative conditions, into a drug candidate. It demonstrates well why medical development takes a long time, more than a decade so far in this case even prior to entering the regulatory process. Each step in the process can take years to work through, funding is ever a problem, and there are frequent delays and dead ends. In 2004, researchers were running an experiment on a group of mice that had been genetically engineered to develop Alzheimer's disease p...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
More News: ALS | Alzheimer's | Brain | Neurology | Parasitic Diseases | Parasitology | Parkinson's Disease | Research | Study