Psychophysical well ‐being profiles in patients before hematopoietic stem cell transplantation

Abstract ObjectivesThe literature offers very few in‐depth reports on the time directly before hematopoietic stem cell transplantation (HSCT). Also, researchers have focused on selected aspects of psychophysical well‐being and treated the sample as homogeneous. Thus, we chose to investigate distinct multidimensional well‐being profiles (including anxiety, depressive symptoms, and health‐related quality of life [HRQOL] domains) among patients just before HSCT, as well as profile predictors (generalized self‐efficacy) and outcomes (transplant appraisal) based on the transactional stress model. MethodsDepression (CES‐D), anxiety (HADS‐A), HRQOL (EORTC QOL‐C30), generalized self‐efficacy (GSES), and transplant appraisal (single‐item scale referred to threat and challenge) were measured in 290 patients (56.9% male; mean age = 47.28, SD = 13.79) after admission for HSCT (67.2% autologous). Unconditional and conditional latent profile analyses (LPA) were applied. ResultsFour latent well‐being profiles were identified: well‐functioning (51%, highest well‐being in all aspects), dysfunctional (10%, weakest functioning in all aspects), and two profiles with moderate HRQOL and high (5.6%) or low (33.4%) anxiety and depressive symptoms. Generalized self‐efficacy predicted profile membership, controlling for demographic and clinical variables. The highest levels were observed in the well‐functioning group (p
Source: Psycho-Oncology - Category: Cancer & Oncology Authors: Tags: PAPER Source Type: research

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CONCLUSION: Our finding suggests the importance of psychiatric approaches, including preventive measures, for the patients undergoing HSCT. PMID: 31558690 [PubMed - as supplied by publisher]
Source: Psychiatry Investigation - Category: Psychiatry Tags: Psychiatry Investig Source Type: research
Abstract Chronic pain is a common condition that seriously affects the quality of human life with variable etiology and complicated symptoms; people who suffer from chronic pain may experience anxiety, depression, insomnia, and other harmful emotions. Currently, chronic pain treatments are nonsteroidal anti-inflammatory drugs and opioids; these drugs are demonstrated to be insufficient and cause severe side effects. Therefore, research into new therapeutic strategies for chronic pain is a top priority. In recent years, stem cell transplantation has been demonstrated to be a potent alternative for the treatment of ...
Source: Current Stem Cell Research and Therapy - Category: Stem Cells Authors: Tags: Curr Stem Cell Res Ther Source Type: research
To investigate the cognitive and psychological outcomes of pediatric allogeneic HSCT survivors in China. A total of 135 3 to 18 years old children and adolescents who underwent allo-HSCT and survived at least 3 months post-HSCT were recruited and completed the assessments. Cognitive and psychological functions were assessed via age-appropriate standardized measures. Clinical information was extracted from the medical records. Forty one 3 to 6 years old children completed Psychological Questionnaires for 3 to 6 years Children. The scores of 21(51.2%) children in cognitive development dimension, 18(43.9%) in motor developm...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
Source: Journal of Psychosocial Oncology - Category: Cancer & Oncology Authors: Source Type: research
Psychiatric care is an important aspect of Hematopoietic Stem Cell Transplantation (SCT) because of high rates of acute and chronic anxiety, depression, delirium, cognitive impairment [1], decreased quality of life, body image disturbances, and post-traumatic stress [2, 3]. The use of psychosocial rating scales is potentially useful to integrate psychiatric evaluation findings into medical risk stratification models in transplantation, but has not been studied in SCT. The Stanford Integrated Psychosocial Assessment for Transplantation (SIPAT) is a structured assessment tool with demonstrated inter-rater reliability.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research
ConclusionsThis survey confirmed the heterogeneity of alpha-mannosidosis and the large impact of the disease and treatment on patients, carers, and families. Early diagnosis and access to treatment offers the best chance of slowing the disease progression and may provide some relief to patients and carers.
Source: Molecular Genetics and Metabolism Reports - Category: Genetics & Stem Cells Source Type: research
Conclusion: Our data suggest that mirtazapine can attenuate hepatic innate immune responses that critically regulate the subsequent development of autoimmune liver injury. Therefore, given that it is a safe and widely used medication, mirtazapine may represent a novel therapeutic approach to autoimmune liver disease. Introduction Classically, autoimmune disease was considered a disorder of adaptive immunity (1). However, early innate immune responses are clearly important for driving subsequent adaptive immune responses in autoimmunity. In numerous autoimmune disease models, activation of resident tissue macrophages,...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Ryan R. Kelly1,2†, Lindsay T. McDonald1,2†, Nathaniel R. Jensen1,2, Sara J. Sidles1,2 and Amanda C. LaRue1,2* 1Research Services, Ralph H. Johnson VA Medical Center, Charleston, SC, United States 2Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, United States The significant biochemical and physiological effects of psychological stress are beginning to be recognized as exacerbating common diseases, including osteoporosis. This review discusses the current evidence for psychological stress-associated mental health disorders as risk factors for os...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
There is nothing more frustrating than when the cure is part of the problem. Because depression is prevalent in patients with physical disorders like cancer, stroke, and heart disease, medications often interact with each other, complicating treatment. To appropriately manage depression, you and your physician need to evaluate all medications involved and make sure they aren’t cancelling each other out. A review in the journal Dialogues in Clinical Neuroscience a while back highlighted certain medications that can cause depression. The following are medications to watch out for. Medications to Treat Seizures and Park...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Depression Medications Drug Interactions Mood Disorder Source Type: blogs
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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