Mozart's music in children with drug-refractory epileptic encephalopathies: Comparison of two protocols

In conclusion, the present study seems to confirm that music therapy may be an additional, nonpharmacological, effective treatment for patients with refractory epileptic seizures in childhood. The Mozart's set of different compositions can be better accepted and effective than the K448.
Source: Epilepsy and Behavior - Category: Neurology Source Type: research

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This article highlights the major reflections of ancient Greek mythology in modern neuroscience. An analysis of ancient Greek texts and medical literature using the MeSH term mythology was performed to identify mythological references pertaining to neuroscience. The findings are discussed in relation to etymology, early conceptualization of the nervous system structure and function, incipient characterization of neuropsychiatric disease, and philosophical stance to the practice of medicine in ancient Greece. The search identified numerous observations in clinical neurology (e.g., stroke, epilepsy, cognitive and movement di...
Source: Journal of the History of the Neurosciences - Category: Neuroscience Tags: J Hist Neurosci Source Type: research
Publication date: Available online 16 October 2018Source: Epilepsy &Behavior Case ReportsAuthor(s): Takefumi Hitomi, Morito Inouchi, Katsuya Kobayashi, Shamima Sultana, Takeshi Inoue, Yuko Nakayama, Akihiro Shimotake, Masao Matsuhashi, Riki Matsumoto, Kazuo Chin, Ryosuke Takahashi, Akio IkedaAbstractTo clarify the effects of sleep on cortical irritability in benign adult familial myoclonus epilepsy (BAFME). We retrospectively compared epileptiform discharges of electroencephalographies (EEGs) between awake and sleep periods in 5 patients (mean age: 49.6 ± 20.3 years). We also analyzed polysomnography (PSG)...
Source: Epilepsy and Behavior Case Reports - Category: Neurology Source Type: research
Epilepsy with continuous spikes and waves during slow sleep (ECSWS) is associated with cognitive deficits. The underlying mechanism is thought to relate to disturbance of functions of the foci by the persistent epileptic activity. However, the relationship between epileptic foci and cognitive deficits remains largely unknown, except for in Landau –Kleffner syndrome. The aim of this study was to evaluate the relationship of epileptic foci estimated from magnetoencephalography (MEG) with cognitive functions at the period of diagnosis in non-lesional ECSWS children, excluding those with Landau–Kleffner syndrome.
Source: Brain and Development - Category: Neurology Authors: Tags: Original article Source Type: research
AbstractSlow waves recorded with EEG in NREM sleep are indicative of the strength and spatial extent of synchronized firing in neuronal assemblies of the cerebral cortex. Slow waves often appear in the A1 part of the cyclic alternating patterns (CAP), which correlate with a number of behavioral and biological parameters, but their physiological significance is not adequately known. We automatically detected slow waves from the scalp recordings of 37 healthy patients, visually identified CAP A1 events and compared slow waves during CAP A1 with those during NCAP. For each slow wave, we computed the amplitude, slopes, frequen...
Source: Anatomy and Embryology - Category: Anatomy Source Type: research
Lennox-Gastaut syndrome (LGS) is the most common epileptic encephalopathy in children presenting between 3 and 5 years of age. It is a complex age-related epilepsy syndrome with multiple possible etiologies such as hypoxic ischemic injuries, genetic syndromes, cerebral cortical malformations, and tumors. The etiology may remain elusive in approximately 25% of the cases.1 Similar to many other childhood epilepsy syndromes, the age at onset can be variable but can be delayed into adulthood. LGS is characterized by multiple seizure types, abnormal EEG characteristics, and cognitive decline. Nonconvulsive status epilepticus, p...
Source: Neurology Clinical Practice - Category: Neurology Authors: Tags: All Neuropsychology/Behavior, All Epilepsy/Seizures, Antiepileptic drugs, EEG Editorial Source Type: research
Study Objectives:Dravet syndrome is a severe developmental and epileptic encephalopathy, in which 75% of patients have sleep disturbance. Melatonin is often used for sleep problems in childhood; however, there is no quality evidence supporting its use in Dravet syndrome. We hypothesized that melatonin would increase total sleep and quality of life for patients with Dravet syndrome.Methods:A double-blind crossover randomized placebo-controlled trial was conducted, comparing 6 mg regular-release melatonin to placebo for patients with Dravet syndrome and sleep disturbance. The primary outcome measure was total sleep measured ...
Source: Journal of Clinical Sleep Medicine : JCSM - Category: Sleep Medicine Source Type: research
In this study, we aimed to assess vPSG findings in consecutive patients with a clinical diagnosis of NREM-parasomnia covering the whole phenotypic spectrum. Five hundred and twelve patients with a final diagnosis of NREM parasomnia who had undergone vPSG were retrospectively identified. vPSGs were analysed for features of NREM parasomnia and for the presence of other sleep disorders. Two hundred and six (40.0%) patients were clinically diagnosed with sleepwalking, 72 (14.1%) with sleep terrors, 39 (7.6%) with confusional arousals, 15 (2.9%) with sexsomnia, seven (1.4%) with sleep-related eating disorder, 122 (23.8%) with m...
Source: Journal of Sleep Research - Category: Sleep Medicine Authors: Tags: J Sleep Res Source Type: research
Publication date: November 2018Source: Epilepsy &Behavior, Volume 88Author(s): Jacopo Lanzone, Lorenzo Ricci, Giovanni Assenza, Martina Ulivi, Vincenzo Di Lazzaro, Mario TombiniAbstractObjectiveTransient epileptic amnesia (TEA) is an underestimated condition in emergency clinical setting, where most of transient amnesic episodes tend to be classified as transient global amnesia (TGA). We designed this study to evaluate the actual frequency of TEA in a real-life scenario and to highlight the features that can help clinicians distinguishing it from TGA.MethodsWe retrospectively collected clinical data of 83 patients who ...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
(Ruhr-University Bochum) Researchers from Ruhr-Universit ä t Bochum and the University of Bonn have investigated which activity patterns occur in the brain when people remember or forget things. They were interested in how the brain replays and stores during sleep what it had learned before. The team recorded the brain activity of epilepsy patients who had electrodes implanted into their brain for the purpose of surgical planning. One result: During sleep, the brain even reactivates memory traces that it can no longer remember later on.
Source: EurekAlert! - Social and Behavioral Science - Category: International Medicine & Public Health Source Type: news
Abstract OBJECTIVE: Transient epileptic amnesia (TEA) is an underestimated condition in emergency clinical setting, where most of transient amnesic episodes tend to be classified as transient global amnesia (TGA). We designed this study to evaluate the actual frequency of TEA in a real-life scenario and to highlight the features that can help clinicians distinguishing it from TGA. METHODS: We retrospectively collected clinical data of 83 patients who accessed our emergency ward for an abrupt onset of amnesic disorder, initially interpreted as TGA. All patients underwent neurological evaluation, magnetic reson...
Source: Epilepsy and Behaviour - Category: Neurology Authors: Tags: Epilepsy Behav Source Type: research
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