212Pb-labeled B7-H3-targeting antibody for pancreatic cancer therapy in mouse models

In this study, we tested the binding of radiolabeled mAb 376.96 to human pancreatic ductal adenocarcinoma (PDAC) cells and localization in xenografts in immune-deficient mice and evaluated 212Pb-labeled 376.96 (212Pb-376 .96) for PDAC therapy.

Source: Nuclear Medicine and Biology - December 23, 2017 Category: Nuclear Medicine Authors: Benjamin B. Kasten, Abhishek Gangrade, Harrison Kim, Jinda Fan, Soldano Ferrone, Cristina R. Ferrone, Kurt R. Zinn, Donald J. Buchsbaum Source Type: research