Alteration of the tumor stroma using a consensus DNA vaccine targeting Fibroblast Activation Protein (FAP) synergizes with anti-tumor vaccine therapy in mice.

CONCLUSIONS: These results suggest that immune therapy targeting tumor antigens in combination with a micro-consensus FAP vaccine provides a two fisted punch inducing responses that target both the tumor microenvironment and tumor cells directly. PMID: 29269377 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/29269377?dopt=Abstract

Source: Clinical Cancer Research - December 21, 2017 Category: Cancer & Oncology Authors: Duperret EK, Trautz A, Ammons D, Perales-Puchalt A, Wise MC, Yan J, Reed C, Weiner DB Tags: Clin Cancer Res Source Type: research