Three new pyrrole alkaloids from the roots of Lepidium meyenii

Publication date: February 2018 Source:Phytochemistry Letters, Volume 23 Author(s): Min Zhou, Rui-Qi Zhang, Yan-Jun Chen, Ling-Min Liao, Yan-Qi Sun, Zu-Hong Ma, Qiao-Fen Yang, Ping Li, Yan-Qing Ye, Qiu-Fen Hu Three new pyrrole alkaloids macapyrrolins A–C (1–3) were isolated from the roots of Lepidium meyenii collected from Lijiang, Yunnan province in China. Their structures were elucidated by extensive NMR and MS spectroscopic analyses. Interestingly, macapyrrolins A–C represent the first examples of pyrrole alkaloids found in Lepidium meyenii with a benzyl substituent attached to the pyrrole nucleus. All the isolated macapyrrolins were evaluated for their cytotoxicity against five human cancer cell lines. However, no significant activities were detected at concentrations up to 40μM. Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research