The impact on high-grade serous ovarian cancer of obesity and lipid metabolism-related gene expression patterns: the underestimated driving force affecting prognosis.

The impact on high-grade serous ovarian cancer of obesity and lipid metabolism-related gene expression patterns: the underestimated driving force affecting prognosis. J Cell Mol Med. 2017 Dec 20;: Authors: Cuello MA, Kato S, Liberona F Abstract To investigate whether specific obesity/metabolism-related gene expression patterns affect the survival of patients with ovarian cancer. Clinical and genomic data of 590 samples from the high-grade ovarian serous carcinoma (HGOSC) study of The Cancer Genome Atlas (TCGA) and 91 samples from the Australian Ovarian Cancer Study were downloaded from the International Cancer Genome Consortium (ICGC) portal. Clustering of mRNA microarray and reverse-phase protein array (RPPA) data was performed with 83 consensus driver genes and 144 obesity and lipid metabolism-related genes. Association between different clusters and survival was analyzed with the Kaplan-Meier method and a Cox regression. Mutually exclusive, co-occurrence and network analyses were also carried out. Using RNA and RPPA data, it was possible to identify two subsets of HGOSCs with similar clinical characteristics and cancer driver mutation profiles (e.g. TP53), but with different outcome. These differences depend more on up-regulation of specific obesity and lipid metabolism-related genes than on the number of gene mutations or copy number alterations. It was also found that CD36 and TGF-ß are highly up-regulated at the protein levels...
Source: J Cell Mol Med - Category: Molecular Biology Authors: Tags: J Cell Mol Med Source Type: research