Keeping the Holidays Allergy and Asthma-Free
Title: Keeping the Holidays Allergy and Asthma-FreeCategory: Health NewsCreated: 12/21/2017 12:00:00 AMLast Editorial Review: 12/22/2017 12:00:00 AM
ConclusionsExposure to household pollution is associated with poorer control, greater severity, and poorer pulmonary function; double-exposed individuals have a greater risk of severe asthma and decreased lung function than those exposed only to household pollution.
This global, randomized, double-blind, 26-week trial in 11,729 patients with persistent asthma demonstrated that mometasone furoate-formoterol does not increase serious asthma outcome risk and reduces asthma exacerbation risk compared with mometasone furoate alone.
ConclusionDysfunctional breathing is common in difficult asthma and associated with worse asthma status and unemployment. The independent association with psychological disorders and nasal obstruction highlight an important interaction between comorbid treatable traits in difficult asthma.
Publication date: Available online 7 December 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): T. Sinai, M.R. Goldberg, L. Nachshon, R. Amitzur-Levy, T. Yichie, Y. Katz, E. Monsonego-Ornan, A. ElizurAbstractBackgroundGrowth impairment was previously described in milk-allergic children but was not examined in adults upon reaching final height.ObjectivesTo investigate the dietary intake and final stature of young adults with IgE-mediated cow’s milk-allergy (IgE-CMA) as compared to non-allergic controls.Methods87 IgE-CMA patients, median age 19.5 years (IQR, 17.3-22.7) and 36 control par...
(MedPage Today) -- Norwegian data find association; immune dysregulation may be common thread
Publication date: Available online 7 December 2018Source: Journal of Molecular BiologyAuthor(s): Jan-Philipp Scheide-Noeth, Maximilian Rosen, David Baumstark, Harald Dietz, Thomas D. MuellerAbstractInterleukin-5 (IL-5) is a TH2 cytokine involved in many aspects of eosinophil life. Eosinophilic granulocytes play a pathogenic role in the progression of atopic diseases, such as allergy, asthma and atopic dermatitis and hypereosinophilic syndromes. Here, eosinophils upon activation degranulate leading to the release of proinflammatory proteins and mediators stored in intracellular vesicles termed granula thereby causing local ...
Does respiratory syncytial virus infection in early infancy lead to an increased risk of asthma and respiratory allergies in later childhood?Southern Medical Journal
Providers caring for patients with mastocytosis are tasked with the decision to consider therapeutic options. This may come with some trepidation since the information available in the public domain lists numerous mast cell activators based on data that does not discriminate between primates, rodents and mast cell lines, does not consider dosage and does not take into account previous exposure and resultant clinical findings. This being said, there is support in the literature for an enhanced mast cell response in some patients with mastocytosis and where there is higher incidence of adverse reactions associated with certa...
We have identified and followed-up exhaled molecular phenotypes of severe asthma, which were associated with changing inflammatory profile and oral steroid usage. This suggests that breath analysis might contribute to the management of severe asthma.
Anaphylaxis represents a severe allergic reaction that is rapid in onset and can be fatal 1. Epinephrine is the first-choice medication in the treatment of anaphylaxis, both in the community and in the hospital setting 2. Nonetheless, epinephrine is largely underused 3. The purpose of this study was to examine the reasons that currently motivate professionals to treat anaphylaxis with epinephrine in the Emergency Department (ED) and the prescription of EAI for outpatient use after the allergy workup.