The Magic of Crystal Structure-Based Inhibitor Optimization: Development of a Butyrylcholinesterase Inhibitor with Picomolar Affinity and in Vivo Activity

Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.7b01086

Source: Journal of Medicinal Chemistry - December 22, 2017 Category: Chemistry Authors: Urban Kos ̌ak, Boris Brus, Damijan Knez, Simon Žakelj, Jurij Trontelj, Anja Pišlar, Roman Šink, Marko Jukič, Marko Živin, Adrian Podkowa, Florian Nachon, Xavier Brazzolotto, Jure Stojan, Janko Kos, Nicolas Coquelle, Kinga Sałat, Jacques-Philip Source Type: research