FDA to Remove Boxed Warning From Some Asthma Meds

The FDA will remove a Boxed Warning from certain inhaled medications used to treat asthma and chronic obstructive pulmonary disease (COPD).
Source: WebMD Health - Category: Consumer Health News Source Type: news

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Publication date: Available online 13 December 2018Source: Chemico-Biological InteractionsAuthor(s): Kamal Dua, Vamshikrishna Malyla, Gautam Singhvi, Ridhima Wadhwa, Rapalli Vamshi Krishna, Shakti Dhar Shukla, Madhur D. Shastri, Dinesh Kumar Chellappan, Pawan Kumar Maurya, Saurabh Satija, Meenu Mehta, Monica Gulati, Nicole Hansbro, Trudi Collet, Rajendra Awasthi, Gaurav Gupta, Alan Hsu, Philip M. HansbroAbstractOxidative stress is intensely involved in enhancing the severity of various chronic respiratory diseases (CRDs) including asthma, chronic obstructive pulmonary disease (COPD), infections and lung cancer. Even though...
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
ConclusionsPreventable hospitalization rates are high among public housing residents, and vary significantly by development and condition. By providing geographically granular information, geocoded hospital discharge data can serve as a valuable tool for health assessment and engagement of the healthcare sector and other stakeholders in interventions that address health inequities.
Source: American Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
Mepolizumab, a humanised monoclonal antibody that neutralises interleukin-5, reduces exacerbations of severe eosinophilic asthma and chronic obstructive pulmonary disease (COPD) [1, 2]. The beneficial effect of treatment is most obvious in patients with a raised peripheral blood eosinophil count, a group who are at high risk of exacerbation off treatment [2, 3]. Even in this population, exacerbation rates whilst receiving mepolizumab are around one per patient per year. The nature of these remaining exacerbations has not been described. We carried out a post hoc comparison of exacerbations occurring during treatment with m...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Original Articles: Research letters Source Type: research
The efficacy, safety and positioning of inhaled corticosteroids (ICS) in the treatment of patients with chronic obstructive pulmonary disease (COPD) is much debated, since it can result in clear clinical benefits in some patients ("friend") but can be ineffective or even associated with undesired side effects, e.g. pneumonia, in others ("foe"). After critically reviewing the evidence for and against ICS treatment in patients with COPD, we propose that: 1) ICS should not be used as a single, stand-alone therapy in COPD; 2) patients most likely to benefit from the addition of ICS to long-acting bronchodil...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Reviews Source Type: research
Respiratory disease is a major component of the global burden of disease, with a reduction in deaths from childhood pneumonia but an increase in chronic respiratory disease over the past few decades [1–3]. There is an increasing recognition that low lung function poses a major risk for acute and chronic lung disease. Lung function tracks closely along centiles throughout childhood [4, 5], with lung function at birth determining lung function in later life [6]. Childhood asthma is associated with low lung function [7, 8], with the deficit seen on the first occasion that it is measured. Low lung function in childhood, ...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Editorials Source Type: research
ABSTRACT The study of the human microbiome-and, more recently, that of the respiratory system-by means of sophisticated molecular biology techniques, has revealed the immense diversity of microbial colonization in humans, in human health, and in various diseases. Apparently, contrary to what has been believed, there can be nonpathogenic colonization of the lungs by microorganisms such as bacteria, fungi, and viruses. Although this physiological lung microbiome presents low colony density, it presents high diversity. However, some pathological conditions lead to a loss of that diversity, with increasing concentrations of so...
Source: Jornal Brasileiro de Pneumologia - Category: Respiratory Medicine Source Type: research
ABSTRACT The study of the human microbiome-and, more recently, that of the respiratory system-by means of sophisticated molecular biology techniques, has revealed the immense diversity of microbial colonization in humans, in human health, and in various diseases. Apparently, contrary to what has been believed, there can be nonpathogenic colonization of the lungs by microorganisms such as bacteria, fungi, and viruses. Although this physiological lung microbiome presents low colony density, it presents high diversity. However, some pathological conditions lead to a loss of that diversity, with increasing concentrations of so...
Source: Jornal Brasileiro de Pneumologia - Category: Respiratory Medicine Source Type: research
ABSTRACT The study of the human microbiome-and, more recently, that of the respiratory system-by means of sophisticated molecular biology techniques, has revealed the immense diversity of microbial colonization in humans, in human health, and in various diseases. Apparently, contrary to what has been believed, there can be nonpathogenic colonization of the lungs by microorganisms such as bacteria, fungi, and viruses. Although this physiological lung microbiome presents low colony density, it presents high diversity. However, some pathological conditions lead to a loss of that diversity, with increasing concentrations of so...
Source: Jornal Brasileiro de Pneumologia - Category: Respiratory Medicine Source Type: research
ABSTRACT The study of the human microbiome-and, more recently, that of the respiratory system-by means of sophisticated molecular biology techniques, has revealed the immense diversity of microbial colonization in humans, in human health, and in various diseases. Apparently, contrary to what has been believed, there can be nonpathogenic colonization of the lungs by microorganisms such as bacteria, fungi, and viruses. Although this physiological lung microbiome presents low colony density, it presents high diversity. However, some pathological conditions lead to a loss of that diversity, with increasing concentrations of so...
Source: Jornal Brasileiro de Pneumologia - Category: Respiratory Medicine Source Type: research
ABSTRACT The study of the human microbiome-and, more recently, that of the respiratory system-by means of sophisticated molecular biology techniques, has revealed the immense diversity of microbial colonization in humans, in human health, and in various diseases. Apparently, contrary to what has been believed, there can be nonpathogenic colonization of the lungs by microorganisms such as bacteria, fungi, and viruses. Although this physiological lung microbiome presents low colony density, it presents high diversity. However, some pathological conditions lead to a loss of that diversity, with increasing concentrations of so...
Source: Jornal Brasileiro de Pneumologia - Category: Respiratory Medicine Source Type: research
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