Dysregulation of microRNA biogenesis machinery and microRNA/RNA ratio in skeletal muscle of amyotrophic lateral sclerosis mice

Discussion: We propose that a dysregulation in the miRNA/totRNA ratio in the TA muscle from SOD1G93A mice reflects a pathological increase in miRNA biogenesis machinery. Alterations in the miRNA/totRNA ratio influence the levels of reference noncoding RNAs and may therefore potentially compromise the accuracy of commonly used miRNA normalization strategies. Muscle Nerve, 2017

http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1002%2Fmus.26039

Source: Muscle and Nerve - December 22, 2017 Category: Internal Medicine Authors: Aaron P. Russell, Lobna Ghobrial, Shyuan Ngo, Justin Yerbury, Evelyn Zacharewicz, Roger Chung, S éverine Lamon Tags: Basic Science Research Article Source Type: research