Janssen Enters Worldwide Collaboration and License Agreement with Chinese Company Legend Biotech to Develop Investigational CAR-T Anti-Cancer Therapy
AbstractPurpose of ReviewModern cancer therapy comes at a cost of increased risk of cardiotoxicity. The purpose of our paper is to provide an updated review highlighting research incorporating biomarkers and imaging findings for the detection of subclinical cardiac dysfunction and management of cancer treatment-related cardiotoxicity.Recent FindingsBiomarkers, particularly troponin, NTproBNP, and myeloperoxidase, have been shown to have a predictive role in the development of cancer treatment-related cardiotoxicity. Early reductions in global longitudinal strain and the more recently reported, circumferential strain, have ...
Due to the success of current treatments, patients are living longer and surviving cancer. However, certain treatments can cause cardiac complications which have a significant impact on the individual... Author: VJHemOnc Added: 06/21/2018
With the increasing life expectancy of cancer patients, the long-term consequences of cancer therapy are becoming an increasing issue. Anthracycline-induced heart failure is a classic example of an ad... Author: VJHemOnc Added: 06/21/2018
Cancer research will accelerate meaningfully towards the goal of control of all cancer only when a majority of researchers are working on mechanisms common to large number of different cancer types. There are too many subtypes of cancer and too few scientists to make real progress when tackling cancers one by one. Shutting down metastasis is one grail of cancer research, as the majority of cancer deaths are caused when cancer spreads throughout the body, not by the initial tumor. Thus a search for common mechanisms of metastasis is one of the few presently viable approaches to the production of broader cancer therapies. Re...
Patients with oral cancer can develop complications related to the tumor, the treatment, or patient factors. Surgery, radiotherapy, chemotherapy, or some combinations of these treatments are used for oral cancer, depending on the type of cancer, anatomic site, and stage. The major objectives of oral cancer therapy are complete control of the tumor with minimal complications and better quality of life for the patient. The development of acute or long-term toxicities can limit the patient's tolerance to therapy, sometimes leading to a suboptimal treatment schedule, poor patient outcome, increased hospital stays, and higher treatment costs.
What are the specific challenges faced by older persons with regards to systemic anti-cancer therapy, and how can we improve cancer therapeutics for this population?Age and Ageing
ACS Applied Materials&InterfacesDOI: 10.1021/acsami.8b03521
ACS Applied Materials&InterfacesDOI: 10.1021/acsami.8b04847
In this study, the potential for SWNHs to serve as nanotheranostic vehicles is demonstrated through simultaneous delivery of the chemotherapeutic cisplatin from SWNH cone interiors and imaging of the nanoparticle transport to tumor cells using conjugated quantum dots (QDs). Following the formation of cisplatin-modified SWNH-QD (SWNH-QD + cis) hybrids, their characterization by scanning and transmission electron microscopy (STEM, TEM), energy dispersive spectroscopy (EDS), and dynamic light scattering (DLS) were performed to characterize the composite nanoparticles. Drug release profiles and 50% inhibitory concent...
CONCLUSION:There has been a continuing increase in the number of studies on therapeutic stem cells and CSC-specific markers for selective diagnosis and therapy of cancer. This review focuses on the current status in the use of normal stem cells and CSCs for targeted cancer therapy. Future direction is also proposed.