Spontaneous Hepatitis B Seroclearance upon Development of Hepatocellular Carcinoma
We describe two novel cases of spontaneous hepatitis B seroclearance following the development of HCC, prior to resection. Following resection, specimens were HBsAg- and HBcAg-negative in both tumor and peritumor tissues. Although the precise mechanism of this is poorly understood, nonuniform integration of hepatitis B virus DNA within the liver could lead to selective tumorigenesis of HBsAg-producing cells, explaining the observed clearance of serum HBsAg with the development of HCC.Case Rep Gastroenterol 2017;11:797 –802
Source: Case Reports in Gastroenterology - Category: Gastroenterology Source Type: research
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