Is sperm hyaluronic acid binding ability predictive for clinical success of intracytoplasmic sperm injection: PICSI vs. ICSI?

Is sperm hyaluronic acid binding ability predictive for clinical success of intracytoplasmic sperm injection: PICSI vs. ICSI? Syst Biol Reprod Med. 2014 Aug 14;:1-7 Authors: Mokánszki A, Tóthné EV, Bodnár B, Tándor Z, Molnár Z, Jakab A, Ujfalusi A, Oláh E Abstract Abstract Although intracytoplasmic sperm injection (ICSI) is now a widely-used technique, it is still of interest to improve our knowledge as to which is the best spermatozoon to be selected for ICSI. Infertile men have increased risks of producing aneuploid spermatozoa. Using hyaluronic acid (HA)-binding sperm selection may reduce the genetic risks such as chromosomal aberrations of offspring. In the present study we examined the clinical success of ICSI with HA-selected sperm ('physiologic' ICSI, PICSI) compared to conventional ICSI, as well as the necessity to differentiate patients according to the initial HA-binding assay result (HBA score) and whether the sperm concentration or HBA score can provide additional information. We observed a significantly higher fertilization rate (FR) of the PICSI group with>60% HBA, implantation rate (IR) of the PICSI group with ≤60% HBA, and clinical pregnanacy rate (CPR) in every PICSI group compared to the ICSI groups (p 
Source: Systems Biology in Reproductive Medicine - Category: Reproduction Medicine Authors: Tags: Syst Biol Reprod Med Source Type: research

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A new study on how and when the precursors to eggs and sperm are formed during development could help pave the way for generating egg and sperm cells in the lab to treat infertility.The study, published in the journal Cell Reports, describes the way in which human stem cells evolve into germ cells, the precursors for egg and sperm cells.“Right now, if your body doesn’t make germ cells then there’s no option for having a child that’s biologically related to you,” said Amander Clark, the study’s lead author, a member of the Eli and Edythe Broad Center of Regenerative Medicine and Stem...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
Abstract Cancer is the second major cause of death in the world. The problem of post-cancer infertility plays a significant role, because chemotherapy can be gonadotoxic. Cryopreservation of ovarian tissue before cancer therapy with re-implantation after convalescence is the potential key solution to this problem. The aim of this study was to test the viability of cryopreserved human ovarian cortex after long-term cooling in culture medium composed of permeable cryoprotectants. Ovarian fragments from sixteen patients were randomly divided into two groups. After the operation, tissue pieces assigned to both groups ...
Source: Cryobiology - Category: Biology Authors: Tags: Cryobiology Source Type: research
ConclusionsThe rate of successful TESE and the ICSI outcome in cancer survivors with NOA and RE/FOE is the same as non-cancer azoospermic patients. Female partner age (older than 40  years) was associated with a significant reduction in live birth rates after TESE-ICSI procedures.
Source: Journal of Assisted Reproduction and Genetics - Category: Reproduction Medicine Source Type: research
ConclusionsThe quantity of TQBs available for transfer or cryopreservation can provide important predictors for pregnancy and live birth after the first embryo transfer cycle with a single blastocyst. This valuable information may assist with the future application of SBT.
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
CONCLUSIONS: While avoiding unnecessary embryo transfers and miscarriages are important goals, patients and doctors need to be aware of the high cost implications of applying PGT-A using aCGH on polar bodies. FUNDING: This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. The ESTEEM study was funded by the European Society for Human Reproduction and Embryology. Illumina provided microarrays and other consumables necessary for aCGH testing of polar bodies. PMID: 31930663 [PubMed - as supplied by publisher]
Source: BJOG : An International Journal of Obstetrics and Gynaecology - Category: OBGYN Authors: Tags: BJOG Source Type: research
ConclusionsAOA was able to “rescue” the poor reproductive outcomes in certain types of infertile couples with history of failure pregnancy.
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
ConclusionsIn women older than 35, anticipation of the infertility work-up is associated with only a modest increase in the rate of success of IVF-ICSI. In most scenarios, this advantage may compare unfavorably with the chances of natural conception during the 6 months period.
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
Reproduction is generally associated with women and consequently men’s reproductive is often neglected. One clear example of this is the discrepancy in female and male contraceptives. Women have over a dozen types of contraceptives, including hormonal, nonhormonal, barrier, and long-acting reversible contraceptives. In contrast, men have only 2 options: vasectomy and condoms. Men do not have hormonal methods, nor do they have long-acting reversible contraceptives, both of which tend to be the most effective and often the easiest to use (e.g. methods like the IUD you can “set and forget” for years). This d...
Source: blog.bioethics.net - Category: Medical Ethics Authors: Tags: Health Care Justice Author: Campo-Engelstein Fertility reproductive medicine reproductive rights syndicated Women's Reproductive Rights Source Type: blogs
Conclusions: Administration of low-dose hCG from the early follicular phase for PCOS patients undergoing ovarian stimulation with progesterone protocol may lead to slightly more early preovulatory follicles and marginally, but not significantly, higher clinical pregnancy rates. A continuous trial should be performed to explore the effects of supplementation with different doses of hCG from the start of ovarian stimulation in PCOS patients using the progesterone protocol.Clinical Trial Registration:Chictr.org.cn, identifier: ChiCTR-IOR-15007165
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Authors: Chatroudi MH, Khalili MA, Ashourzadeh S, Anbari F, Shahedi A, Safari S Abstract OBJECTIVE: In vitro maturation (IVM) of immature oocytes can be useful for some infertile patients. In IVM programs, the rates of embryo formation and pregnancy are low. Therefore, it is essential to recognize the main factors involved in regulating oocyte maturation in vitro. The purpose of this study was to investigate the effects of growth differentiation factor 9 (GDF9) and cumulus cell (CC) supplementation in IVM medium on the rates of embryo formation and viability of human blastocysts. METHODS: A total of 80 germinal...
Source: Clinical and Experimental Reproductive Medicine - Category: Reproduction Medicine Tags: Clin Exp Reprod Med Source Type: research
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