The pharmacokinetics of intravenous ketorolac in children aged 2 months to 16 years: A population analysis

ConclusionClearance, expressed as L.h−1.kg−1, decreased with age from infancy. A dosing regimen of 0.5 mg.kg−1 every 6 hours maintains a trough concentration larger than 0.37 mg.L−1 in children 9 months to 16 years of age. This dosing regimen is consistent with current recommendations.

http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1111%2Fpan.13302

Source: Pediatric Anesthesia - December 21, 2017 Category: Anesthesiology Authors: James S. McLay, Thomas Engelhardt, Baba S. Mohammed, Gary Cameron, Mindy N. Cohen, Jeffrey L. Galinkin, Uwe Christians, Michael J. Avram, Thomas K. Henthorn, Richard M. Dsida, Brian J. Anderson Tags: RESEARCH REPORT Source Type: research